A history of the study of transmissible spongiform encephalopathies, a subject popularized by the recent "mad cow disease" epidemic in Great Britain. Wickner (National Institutes of Health, Bethesda) summarizes the study of the lethal infectious neurological diseases in sheep, kuru, and man, presenting newer evidence that the yeast Saccharomyces cerevisiae harbors infectious elements also transmitted by a protein (prion). In particular, the author emphasizes the genetics of these diseases, the yeast diseases URE3 and PSI, and speculates on the part that genetics might play in the discovery of other infectious proteins. Distributed by Chapman and Hall. Annotation c. by Book News, Inc., Portland, Or.

Prion Diseases of Mammals and Yeast: Molecular Mechanisms and Genetic Features (Medical Intelligence Unit)

Science & Math

Wickner, Reed B.

Evolution

R G Landes Co

This text describes the intestinal cell interactions which regulate mucosal growth and response throughout life. Experimental work has led to the development of novel methods for isolation and culture of normal postnatal intestinal epithelium and for successful isolation and transplantation of this epithelium with restoration of the mucosal layer. The book decribes methods of colonic mucosal replacement by "seeded" small intestinal epithelium and the heterogeneous cellular events involved in the temporal sequence of mucosal morphogenesis after transplantation. It discusses studies of graft function and temporal changes of digestive enzyme expression, as well as future prospects of this work including application to human tissues.

Small Bowel Enterocyte Culture and Transplantation (Medical Intelligence Unit)

Campbell, Frederick C.

Biological Sciences

The Role of the Liver in Maintaining Glucose Homeostasis (Medical Intelligence Unit)

Medical Books

Davis, Stephen N.

Cherrington, Alan D.

Pagliassotti, Michael J.

Medicine

This text discusses the role of reactive oxygen radicals in the pathogenesis of myocardial ischemia/reperfusion injury. These reactive oxygen species include superoxide radical, hydrogen peroxide, hydroxyl radical and singlet oxygen. The book describes the biochemistry of oxygen radicals, the mechanisms of free radical generation from various potential sources, and their interaction with membrane proteins, which leads to cardiovascular dysfunction and protection based on antioxidants and histidine. The endogenous protection strategies based on ischemic preconditioning and heat stress are also discussed.

Free Radicals, Cardiovascular Dysfunction and Protection Strategies (Medical Intelligence Unit)

Kukreja, Rakesh C.

Hess, Michael L.

<p>This text provides the strategies in multiparameter flow cytometry. It explains the procedures for staining complex populations of cells with up to six anibodies conjugated with different fluorochromes in combination with DNA content measurement simultaneously. Complete descriptions are given for the instrument alignment and for verification for making these complex measurements. The strategies involved in the analysis of eight parameter data are fully detailed.</p>

Multiparameter Flow Cytometry (Medical Intelligence Unit)

Stewart, Carleton C.

Devoted to viable systems, this text provides material on the theoretical and practical aspects of this emerging technology based on the authors' experience with immobilized cells. Divided into two parts, it begins with an evaluation of the merits of the technology, providing a comprehensive review with supporting examples taken from the authors' laboratory where biomass support particle (BSP) systems are studied extensively. The second part of the text considers current theoretical thinking, presenting advances in the theoretical understanding of the mechanisms underlying the behaviour of viable calls in the immobilized state. Mass transfer and reaction of interactions are examined, and a modelling approach to reflect the dynamic nature and the spatial arrangement of viable immobilized cells is introduced.

Studies in Viable Cell Immobilization (Molecular Biology Intelligence Unit Series)

Engineering & Transportation

Colin Webb

Engineering

Devoted to the molecular/cellular determinants of retroviral gene expression, this text briefly covers the history of retroviruses before discussing the determinants of viral gene expression as influenced by the infected host cell. Particular attention is given to the control of viral transcription. The genetic organization of a representative from each of the subgroups of the complex retroviruses (lentiviruses, oncoviruses and spumaviruses) is described and differences among the subgroups compared. The book also explores the role that the infected host plays in controlling viral transcription.

Retroviral Latency (Medical Intelligence Unit)

Laughlin, Mark A., M.D.

Pomerantz, Roger J., M.D.

Lung transplantation is currently an accepted modality for treatment of end-stage lung disease. Pulmonary immunology is an example of an area where each intervention, whether medical or surgical, can be a significant influence. This book simplifies the science of pulmonary immunology for clinicians involved in the management of lung transplant. It begins with the basics of lung immunology and moves on to alterations that develop in the lung allograft as it is subjected to a variety of insults, such as ischemia, reperfusion, infection and the long-term sequella associated with obliterative bronchiolitis and viral infections. The book also addresses how immunosuppressive medications, whether during induction or long-term, may influence the lung allograft immune mechanisms, thereby affecting potential risks of rejection and infection.

Immunology of the Lung Allograft (Medical Intelligence Unit)

Shennib, Hani

The interface between the immune and nervous systems is an increasingly important area of scientific research. These systems are the most complex that we know and their interaction has manifold consequences for understanding a wide variety of both allergic and degenerative diseases. This book is an up-to-date review of research conducted on the main cell of the immune system (macrophage) and its relationship with neuronal cells. The book also highlights studies of macrophage involvement in neurodegenerative diseases, multiple sclerosis and HIV dementia complex.

Macrophages and the Nervous System (Molecular Biology Intelligence Unit)

Perry, V. Hugh

Basic Sciences

Rna Polymerase III Transcription (Molecular Biology Intelligence Unit)

Biographies & Memoirs

White, Robert J.

Leaders & Notable People

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Books by R G Landes Co