This text discusses the role of reactive oxygen radicals in the pathogenesis of myocardial ischemia/reperfusion injury. These reactive oxygen species include superoxide radical, hydrogen peroxide, hydroxyl radical and singlet oxygen. The book describes the biochemistry of oxygen radicals, the mechanisms of free radical generation from various potential sources, and their interaction with membrane proteins, which leads to cardiovascular dysfunction and protection based on antioxidants and histidine. The endogenous protection strategies based on ischemic preconditioning and heat stress are also discussed.

Free Radicals, Cardiovascular Dysfunction and Protection Strategies (Medical Intelligence Unit)

Medical Books

Kukreja, Rakesh C.

Hess, Michael L.

Medicine

R G Landes Co

Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock activated a powerful endogenous protective mechanism that significantly improved myocardial salvage following prolonged ischemia and reperfusion injury in the heart. A characteristic feature of this heat shock response was the expression of a family of proteins known as heat shock proteins. Many of these proteins function as molecular chaperones, helping to refold proteins denatured as a consequence of lethal injuries and facilitating the synthesis of new proteins to replace those irreparably damaged. Altered expression of these proteins has been extensively documented in association with a diverse array of diseases such as ischemia and perfusion injury, cardiac hypertrophy, fever, inflammation, metabolic diseases, infection, cell and tissue trauma, aging, and cancer. Interestingly, some studies have now shown a direct correlation of the heat shock proteins produced and the degree of myocardial protection. This book is a thorough description of the current state of knowledge of the mechanisms of heat shock proteins induced cardiac protection at the cellular and molecular level, the controversies in this growing field and the potential of treating ischemic heart disease with overexpression of heat shock proteins in patients. The book will be especially useful for investigators interested in studying tissue injury and its protection with the overexpression of heat shock proteins.

Heat Shock Proteins in Myocardial Protection: Medical Intelligence Unit 16

Science & Math

Biological Sciences

CRC-Press

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