Page edges tanned. Shipped from the U.K. All orders received before 3pm sent that weekday.

The Haunted Study: A Social History of the English Novel 1875-1914

KEATING, Peter

History

Grange Books

In 1984 Cesar Milstein and Georges Kohler were awarded the Nobel Prize for their discovery of "hybridoma technology", a method leading to the production of unlimited quantities of biological reagents of "exquisite specificity" known as monoclonal antibodies. Focusing on this ground-breaking development in the recent history of the biomedical sciences, this volume offers a description of scientific activity that delineates the development of scientific knowledge. Based on an extensive reading of the literature in the field, interviews with leading participants and on-site observation, the book follows events, materials and actors through a twenty-year period during which a laboratory technique was transformed into one of the most successful tools of modern biotechnology. Beginning with an analysis of the amiguities surrounding the initial status of monoclonal antibodies, the book goes on to explore the various practices and forms of knowledge involved in the reproduction of hybridoma technology. The analysis of the worldwide diffusion of monoclonal antibodies and their consequent transformatin by users is complemented with a close-up account of their adoption within two laboratories. The book ends with a detailed analysis of the patent disputes that have shaped the industrial destiny of monoclonal antibodies.

Exquisite Specificity: The Monoclonal Antibody Revolution

Science & Math

Cambrosio, Alberto

Biological Sciences

Oxford University Press

Cancer on Trial: Oncology as a New Style of Practice

Until the early 1960s, cancer treatment consisted primarily of surgery and radiation therapy. Most practitioners then viewed the treatment of terminally ill cancer patients with heroic courses of chemotherapy as highly questionable. The randomized clinical trials that today sustain modern oncology were relatively rare and prompted stiff opposition from physicians, who were loath to assign patients randomly to competing treatments. Yet today these trials form the basis of medical oncology. How did such a spectacular change occur? How did medical oncology pivot from a nonentity and, in some regards, a reviled practice to the central position it now occupies in modern medicine? In Cancer on Trial Peter Keating and Alberto Cambrosio explore how practitioners established a new style of practice, at the center of which lies the cancer clinical trial. Far from mere testing devices, these trials have become full-fledged experiments that have redefined the practices of clinicians, statisticians, and biologists. Keating and Cambrosio investigate these trials and how they have changed since the 1960s, all the while demonstrating their significant impact on the progression of oncology. A novel look at the institution of clinical cancer research and therapy, this book will be warmly welcomed by historians, sociologists, and anthropologists of science and medicine, as well as clinicians and researchers in the cancer field.

History & Philosophy

University of Chicago Press

Since the end of World War II, biology and medicine have merged in remarkably productive ways. In this book Peter Keating and Alberto Cambrosio analyze the transformation of medicine into biomedicine and its consequences, ranging from the recasting of hospital architecture to the redefinition of the human body, disease, and therapeutic practices. To describe this new alignment between the normal and the pathological, the authors introduce the notion of the biomedical platform. Defined as a specific configuration of instruments, individuals, and programs, biomedical platforms generate routines, entities, and activities, held together by standard reagents and protocols. Biological entities such as cell surface markers, oncogenes, and DNA profiles now exist as both normal biological components of the organism and as pathological signs -- that is, as biomedical substances. The notion of a biomedical platform allows researchers interested in the development of contemporary medicine to describe events and processes overlooked by other approaches.The authors focus on a specific biomedical platform known as immunophenotyping. They describe its emergence as an experimental system with roots in biology (immunology) and pathology (oncology). They recount how this experimental system was transformed into a biomedical platform initially for the diagnosis of leukemia and subsequently for other diseases such as AIDS. Through this case study, they show that a biomedical platform is the bench upon which conventions concerning the biological or normal are connected with conventions concerning the medical or pathological. They observe that new platforms are often aligned with existing ones and integrated into an expanding set of clinical-biological strategies.

Biomedical Platforms: Realigning the Normal and the Pathological in Late-Twentieth-Century Medicine (Inside Technology)

Politics & Social Sciences

Sociology

Mit Pr

Since the end of World War II, biology and medicine have merged in remarkably productive ways. In this book Peter Keating and Alberto Cambrosio analyze the transformation of medicine into biomedicine and its consequences, ranging from the recasting of hospital architecture to the redefinition of the human body, disease, and therapeutic practices. To describe this new alignment between the normal and the pathological, the authors introduce the notion of the biomedical platform. Defined as a specific configuration of instruments, individuals, and programs, biomedical platforms generate routines, entities, and activities, held together by standard reagents and protocols. Biological entities such as cell surface markers, oncogenes, and DNA profiles now exist as both normal biological components of the organism and as pathological signs―that is, as biomedical substances. The notion of a biomedical platform allows researchers interested in the development of contemporary medicine to describe events and processes overlooked by other approaches.
The authors focus on a specific biomedical platform known as immunophenotyping. They describe its emergence as an experimental system with roots in biology (immunology) and pathology (oncology). They recount how this experimental system was transformed into a biomedical platform initially for the diagnosis of leukemia and subsequently for other diseases such as AIDS. Through this case study, they show that a biomedical platform is the bench upon which conventions concerning the biological or normal are connected with conventions concerning the medical or pathological. They observe that new platforms are often aligned with existing ones and integrated into an expanding set of clinical-biological strategies.

Biomedical Platforms: Realigning the Normal And the Pathological in Late-twentieth-century Medicine (Inside Technology Series)

Health, Fitness & Dieting

Bound in the publisher's original burgundy cloth, spine stamped in gilt.

The haunted study: A social history of the English novel, 1875-1914

Literature & Fiction

Secker Warburg

At the age of 57, Peter Keating set out to sail, single-handed, across the Atlantic.\nIt was a lifelong dream of a lifelong sailor and though it was to be a solo journey, his waking and sleeping hours were spent in the 'company' of his memories and erstwhile companions and friends. From Werner and crocodile surfing, to Gerhardt and the Gulag. From Charlie of Morova Lagoon, to Fred from Fransesca. Their stories, along with the Mafiosa of Malta, Leo from the Chesapeake, the myth of Napoleon on St Helena and many more besides, were weaved into Peter's as they hauled along, day after day, from horizon to horizon on the voyage from Norfolk, Virginia to Lisbon, Portugal. 
They were there to help and inspire him and, when he was caught in the middle of Hurricane Barry, to ensure he reached out and survived. When at his lowest ebb, along came the ghost of Sam, a friendly old sailor who kept Peter entertained through the long, lonely hours of the dog watch. 
Together they fill the pages of this book, yet this is not simply a sailing log of a trip from the New World to the Old. This is a story of individuals who have all lived on the edge. It shows what happens when you are brave enough to push yourself beyond your current boundaries and above all, go out on a limb. Yes, it will help you to understand more about deep oceaning, its joys and terrors, but perhaps it will also help the adventurer inside you to reflect on how you would cope in similar circumstances. 
Ultimately, this is not just Peter Keating's journey alone, but the journey of us all when we go out on the edge - to peer over any horizon - and to finally emerge the better for having left our safe harbour.

Sailing on the Edge: Alone Across the Atlantic

Sports & Outdoors

Water Sports

Leschenault Press

Autobiographical tales

Priskus Books

Agatha Christie and Shrewd Miss Marple

GARDNERS VI BOOKS AMS006

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