Selective Laser Spectroscopy of Activated Crys

V. V. Osiko

Nova Biomedical

The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterised receptors: ER&#945; and ER&#946;. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects.

A Handbook on Estrogen Receptors in the Brain (Neuroscience Research Progress)

Medical Books

Paramanik, Vijay

Medicine

It is estimated that 86 million adult Americans have prediabetes and with that, a risk of developing T2DM (type 2 diabetes) within one in ten patients. About 29 million people have actual diabetes, most with T2DM. It was estimated in 2012 that about 208,000 people under the age of 20 have diabetes in the United States, but there is little data available on the prevalence of diabetes in the adolescent population. A recent study looking at 12-19 year olds from 2005-2014 found the prevalence of diabetes at 0.8%, with 28.5% undiagnosed and the prevalence of prediabetes 17.7%, more common among boys (22%) than girls (13.2%). With about 9% of the total US population having diabetes, this a public health issue of considerable proportions. In this book, the reader embarks on a journey through the medical history of the discovery and treatment of diabetes mellitus. It is the story of the human mind steadfastly seeking to understand its world a story worth telling again and again that has saved millions of lives from a premature death of misery in the 20th and now 21st century.

Diabetes Mellitus: A Medical History Journey (Public Health: Practices, Methods and Policies)

Essential Guide to Neonatology is the last handbook any neonatal care provider will need, providing a concise yet comprehensive review of essential topics. While it is handbook-sized, it provides in-depth descriptions of fundamental principles for didactic learning, balanced with practical management pointers. It covers common diagnoses in neonatology (from respiratory distress syndrome to congenital cardiac disease to anemia of prematurity), provides procedural guides (such as lumbar puncture and umbilical line placement), and includes nutritional guidelines for neonates, a comprehensive medication dosing guide, and more. The book is organized by organ systems, and chapters generally provide background didactic information covering basic physiology, diagnostic instruction, as well as management principles based upon evidence-based medicine. Therefore, it can be read from cover to cover to establish a foundation of knowledge for neonatal trainees, or each chapter can be read in isolation as needed for day-to-day practice. Chapters have been authored by a team of multi-disciplinary experts from physicians, to fellows, to respiratory and developmental therapists, to nutritionists, all of who have been recruited from across the US. Therefore, the content of this handbook is accessible at many levels of experience, across many of the disciplines that are essential for providing well-rounded neonatal care, and for any neonatal intensive care unit - from community NICUs to academic institutions. This textbook features: Reader-friendly tables and figures for quick reference Intuitive chapter organization, which provides evidence-based didactic and management information A comprehensive range of topics covered, from basic physiology, to ethical issues, to how to write TPN Practical medication dosing tables throughout the textbook Detailed procedural instruction and rounding tips for trainees

Essential Guide to Clinical Neonatology (Pediatrics - Laboratory and Clinical Research)

Jeanette D. Hoenig

The search for medicinal agents to improve emotional, behavioral, and psychiatric conditions of Homo sapiens has occurred for ages. The 20th century witnessed the development of psychopharmacologic agents, including stimulants in the 1930s (and 1950s), chlorpromazine in the 1950s, lithium, tricyclic antidepressants, benzodiazepines, SSRIs (1990s), and others. The proper use of these agents in the pediatric population continues to be an active study. Atypical antipsychotics have been approved by the FDA for children and adolescents though their safety and efficacy in the pediatric population but must be assiduously ascertained with ongoing research in the eternal iatric maxim of primum non nocere. The science of evidence-based pharmacotherapy for mental health disorders in children and adolescents is finally emerging. Exciting discoveries await the researchers of this still early 21st century lead by the crucial collaborative efforts of academicians, pharmaceutical scientists, and medical government authorities. Controversies regarding the use of various psychopharmacologic agents for the pediatric population continue in the 21st century, requiring further research and insightful judgment for its applications in this vulnerable population. Excessive and unnecessary psychopharmacologic agents should be avoided in the pediatric population with behavioral/emotional/psychiatric conditions/disorders. In this second edition, the authors present updated information about psychopharmacology in childhood and adolescence.

Clinical Aspects of Psychopharmacology in Childhood and Adolescence (Pediatrics, Child and Adolescent Health)

Health, Fitness & Dieting

Psychology & Counseling

Behavioural neurology is a subspecialty of neurology that investigates the neurological basis of human behaviour and cognitive function. Recently, dementing diseases have become so common that their behavioural abnormalities are now being investigated with reference to brain damage. During a big disaster, which can critically affect the human population, people should utilise their brains fully in order to survive, that is, to understand the situation around them, to make a proper judgement, and to decide their behaviours; these are associated with brain functions. However, disaster medicine is focused mainly on the environment, with the underlying assumption that brain function is always normal, and thus judgement and behaviour remain normal. By contrast, dementia medicine does not always consider dementia in determining peoples behaviours during the disaster. The author believes that approaches to brain-based disaster medicine and disaster-associated dementia medicine have not been fully integrated nor even investigated. Herein, the author focuses on reconstruction support after the Great East Japan earthquake in 2011, from an academic perspective, with particular respect to behavioural neurology based on his own experiences.

Cognitive Impairment and Survival After a Natural Disaster: Lessons Learned from Life Experiences in the Great East Japan Earthquake 2011 (Neurology - Laboratory and Clinical Research Developments)

Meguro, Kenichi

The impact of blood viscosity on health and disease has been neglected, even though viscosity is a fundamental property of any fluid. It is inversely proportional to flow, so increased blood viscosity predisposes to thrombosis. Blood viscosity is directly related to systemic vascular resistance, and so blood viscosity affects blood pressure. Blood viscosity is inversely proportional to perfusion, and increased viscosity adversely affects the performance of all organs. By viewing them through the perspective of viscosity, this book provides fresh insight into atherosclerotic cardiovascular disease, hypertension, metabolic syndrome, sepsis, hemolytic anemias, anemia of chronic disease, and aging.

Blood Viscosity: Its Role in Cardiovascular Pathophysiology and Hematology (Pathology Research and Practices)

Gregory D. Sloop

This book focuses on the regulation, function and further research insights on aldosterone. Chapter One discusses the role of aldosterone in the causation of cardiac oedema and highlights areas for potential future research. Chapter Two reviews secondary arterial hypertension due to primary hyperaldosteronism. Chapter Three summarizes the present knowledge about the role of aldosterone in stress adaptation with special emphasize to age-dependent changes. Chapter Four presents an overview of the effects of aldosterone, focusing on nongenomic actions in the kidney.

Aldosterone: Regulation, Function and Research Insights (Endocrinology Research and Clinical Developments)

Jacqueline Miller

This book tackles a complex subject with both science and the heart. A diagnosis of any serious disease is life-altering and frightening. At such times, patients and their families look to their doctors for answers and treatment. Support groups help the newly diagnosed face their challenges and their experiences, removing feelings of isolation. However, when the diagnosis is a rare disorder, especially when diagnosed in an infant, none of that may follow. Genetic Mistakes is about one class of such disorders. These metabolic mistakes strike nearly every cell in the body, reducing energy and threatening a myriad of potential problems from muscle pain and neurological issues to coma and even death. Known as FAODs, or FODs, they present complex problems with no established therapies except dietary restrictions and supplements. Genetic Mistakes provides those affected by FAODs - including patients, parents, and primary medical personnel - with accessible, basic information. While it is not meant to take the place of medical care or medical references, it does offer both layman and primary caregivers a quick link to both current knowledge about FAODs and insight into those who must live with them. Divided into three sections, Genetic Mistakes takes on the science and genetics of FAODs, explaining them in a plain and unemotional, yet sensitive language. The first section deals with understanding FAODs. It relies heavily on both recent and historic scientific studies and will lead the reader to see that while there is no cure, there is hope. It explains how the disorders are inherited, how they affect the body, and how patients can help themselves by understanding both the potential effects of their disorders and how their own behavior might influence it. It teases out the individual FAODs and gives the information most desired by those affected: What tests might I need? What symptoms are common? How severe is this? The second section in Genetic Mistakes addresses the issues of learning to live with FAODs. Whether people are raising a child with one, or must cope with a later-onset FAOD themselves, these pages hold the stories, tips, and wisdom of those who have gone before. It also provides some insight into the research that may provide answers in the future. The final section of Genetic Mistakes is meant as a springboard for readers, providing them with both the references consulted for the book as well as other useful websites, organizations, books, and more to help them understand their disorders and live confident lives. (Imprint: Nova Biomedical)

Genetic Mistakes: Understanding and Living With Fatty Acid Oxidation Disorders (Metabolic Diseases: Laboratory and Clinical Research)

Science & Math

Forrest, Rosemary

Baugh, Nicole

Evolution

Multiple Sclerosis is one of the most common neurological disorders leading to disability. Many cases of Multiple Sclerosis are diagnosed late especially in young patients because providers are not considering it early in their assessment and differential diagnosis. This book will provide an additional resource to health care providers working with children and adolescents to facilitate increased awareness and earlier diagnosis and treatment.

Multiple Sclerosis in Children and Adolescents (Pediatrics, Child and Adolescent Health)

Diseases & Physical Ailments

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