There have been many important advances in our understanding of biological membrane structure and function over the last decade. Much of this progress has been driven by the development of new techniques for studying membrane components and their interactions. Tradition ally, the investigation of membranes has largely occurred within the domains of biochemistry, physical chemistry, and cell biology; but many of the most significant advances have resulted from an expansion into other disciplines, such as molecular biology, immunology, and the clinical sciences. In these two volumes we have attempted to bring together some of these techniques―to combine the old and the new. Biomembrane Protocols: II. Architecture and Function is concerned exclusively with the architecture and activities of membranes, whereas the companion volume, Biomembrane Protocols: I. Isolation and Analysis, deals with their isolation and compositional analysis. The aim of each chapter is to provide detailed technical and meth odological information that will allow the reader to perform the tech nique successfully, without the need to consult other texts. Detailed reviews of membrane structure and function are not included, except where they are relevant to the choice or efficacy of a particular proce dure. In addition to Materials and Methods sections, each chapter has a Notes section that explains the reasons for taking certain steps and pro vides practical tips for applying the techniques to other systems.

Biomembrane Protocols: II. Architecture and Function (Methods in Molecular Biology)

Science & Math

Graham, J. M.

Higgins, J A

Biological Sciences

Humana Press Inc.,U.S.

<p>This handbook offers a collection of detailed descriptions of 50 major laboratory techniques utilized throughout molecular biology and biochemistry (including both nucleic acid and protein methods). The multitude of techniques are described in detail with a comprehensive background outlining the technique followed by a discussion of the application of the technique in the lab.</p>

Molecular Biomethods Handbook

Ralph Rapley

Pediatric Urology

Gearhart, John

Medical Books

After the success of the first edition of Critical Care Neurology and Neurosurgery, I find myself at the helm of this second delivery of the salient advances in the field of neurocritical care. Since the first edition went into print, two major advances in the field have occurred. The first is the creation of the Neurocritical Care Society (www.neurocriticalcare.org) with a peer-reviewed journal published by Humana Press – Neurocritical Care. The second advance is the availability of a certifying examination and credentialing of training programs in neurocritical care via the United Council of Neurological Subspecialties –UCNS (www.ucns.org). These will certainly solidify the practice of caring for the critically ill neurologic and neurosurgical patient as a separate subspecialty. It is with this excitement that this second edition of this title is launched. The organization and length of this book has been changed to reflect discoveries in the field and to keep pace with significant advances. The book has been divided into three distinct sections following an introductory chapter on the basic definitions and triage of the critically ill neurologic and neurosurgical patient, similar to what was presented in the first edition. The primary market is practicing neurologists, neurosurgeons, and neuroanesthesiologists, in particular those with subspecialty interest in neurocritical care. Other clinicians with an interest in neurocritical care are pulmonologists, internists, general surgeons, and anesthesiologists with a subspecialty in critical care. Also neuroradiologists may find this book interesting and of help for their daily clinical practice. This book could also be translated and marketed in spanish and portuguese – speaking countries. There is no single textbook dedicated to neurocritical care in these two languages. I personally would undertake the translation and editing of those editions. The first section deals with the basic principles of neurocritical care and begins with recommendations for the organization of an up-to-date Neurosciences Critical Care Unit. This section will set the foundations for a good understanding of the complex interactions between the brain and different body systems. A discussion on common bioethical issues as well as clinical trial design and research databases is also presented. The second section encompasses common medical complications of the neurocritically ill patient. This section includes the addition of ten completely new chapters discussing the latest advances on secondary systemic complications. The third section presents chapters on frequent primary neurologic and neurosurgical diagnoses and updated therapeutic strategies. In regard to tables and figures/illustrations, I estimate each chapter will have 6 figures and 4-6 tables. I will encourage authors to use illustrations and will try to work with an illustrationist to maintain uniformity of all the graphs. Figures and graphs will be black and white except for appendices N10-12 like in the first edition. Finally, like the first edition, the book concludes with an appendix of different useful equations, tips, and scales that will become handy when working in the Neurosciences Critical Care Unit. One addition is an appendix summarizing the most frequently cited clinical trials in general and neurocritical care.

Critical Care Neurology and Neurosurgery

Jose I. Suarez

Medicine

Adult Stem Cells

Turksen, Kursad

Management of Multiple Drug-resistant Infections

Gillespie, Stephen H.

Methods in Molecular Biology, Volume 252: Ribozymes and siRNA protocols

Sloud, Mouldy

Protein Arrays: Methods and Protocols is an introduction to protein array technology and its application to the multiplexed detection of proteins. Although protein array technology has some roots in gene array technology, it can only be described as a distant relative. Unlike DNA, with its established rules of base pairing, and therefore predictable biochemical behavior, proteins are rich with diversity. Proteins can be large or small, compact or extended, basic or acidic, hydrophobic or hydrophilic, and so on. Just as importantly, their behavior is determined by the environment in which they reside, and so the composition of the buffer in which experiments are performed has a dramatic impact on the outcome of the experiment. Thus, if the goal is to simultaneously measure the expression of a large number of proteins, these variables must be addressed. Not to be deterred, scientists have created a variety of solutions to successfully detect and ch- acterize multiple proteins simultaneously. It is the intent of this volume to introduce to the reader a set of technological solutions to the diversity problem as well as to provide the reader with some examples of practical applications of these technologies.

Protein Arrays

Crafts, Hobbies & Home

Fung, Eric

Antiques & Collectibles

Pain Research

Luo, Z. David

A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in Rna biology, as well as the underpinnings of Rna interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRna. They also provide some examples of how these new therapeutic compounds are being used clinically.

Nucleic Acid Therapeutics in Cancer

Gewirtz, Alan M.

Nursing

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