CHIRAL SEPARATIONS BY HPLC CL (Ellis Horwood Books in the Biological Sciences)

Krstulovic

Medical Books

Taylor & Franci

Addresses experimental and optimization techniques in the context of pharmaceutical research, formulation and manufacture. Specific techniques are described, showing concepts, benefits and limitations. The book includes clinical and consumer trials from a spectrum of pharmaceutical sciences.

Understand Exper Designcl

ARMSTRONG

This introduction to pharmacokinetics has been designed to lead the novice to a sufficiently advanced level to design the appropriate experimental studies as part of the safety evaluation of chemicals. It will be of value to those involved in the development and toxicity assessment of chemicals. The author defines the mechanisms of drug absorption, and influencing factors such as dissolution, gastric emptying and blood flow, as well as modifying factors such as endogenous and exogenous substances. He examines the nature of first-pass effect in the pulmonary, gastrointestinal and hepatic systems, and present animal and clinical studies showing determination of first-pass effect. Further sections of the text survey distribution circulation proteins, tissue distribution, tissue clearance, kinetic data and clinical pharmacokinetics.

HANDBOOK OF PHARMACOKINETICS CL (Ellis Horwood Series in Biomedical Sciences)

Labaune

Tourists in Historic Towns examines the relationship of culture, heritage, conservation and tourism development in historic towns and urban centres, debating the impacts of tourism on historic towns and the role tourism plays in conservation and urban continuity. The main focus of the book is medium sized historic towns and historic quarters which are attractive to the tourist market, but historic quarters in large cities and smaller rural settlements are not excluded. Alongside over a hundred examples of historic towns, five historic towns are discussed as case studies: Granada, Spain; York, England; Mdina, Malta; Antalya, Turkey and Quedlingburg, Germany.

Tourists in Historic Towns

Business & Money

Orbasli, Aylin

Industries

The production of manufactured goods has been a fundamental activity throughout human history and remains essential to the modern world. The challenge of increased productivity has been rooted in the establishment of stable economic growth, especially durign the 1980s, when emphasis was placed on raising industrial output. Increasingly, people believe that the most effective way to increase productivity is by a transformation of science and technology into productive power, whereby scientific research impacts on production. These two volumes contain 495 conference papers by 1135 authors which reflect the newest results in various fields of production. They are aimed at industiral engineers, manufacturing and design engineers and managers, CAD systems developers, organziational / industrial scinetists, researchers in human ractors, OR, and CIM systems.

Transf Scienc & Technol2 V Set

Engineering & Transportation

Ming L

Engineering

Tokyo 1990 1st Japan Scientific Societies. Hardcover. Octavo, 166pp., illustrations, cloth. VG, no DJ.

ENDOSCOPIC APPR CANCER DIAGN (Discontinued(Gann Monographs on Cancer Research))

Oguro & Ta

The 23rd Annual Meeting of the European Society for Radiation Biology was held in Dublin, Ireland, 23rd-26th September 1991. The meeting was structured to address eleven major topics of interest to a wide range of workers in radiobiology, and allied fields. It also provides a forum for free communications in all areas of radiobiological interest. Papers which formed the subject matter of the major symposia are published in these proceedings together with the plenary lectures. Topics for the symposia followed two broad themes. The first theme was to promote areas where new developments in cell and molecular biology are fundamentally altering concepts of radiation action. Two of the plenary lecturers, Professors DiPaolo and Little, reviewed this area, which included symposia on radiation induced mutagenesis and transformation, dosimetry and risk, DNA damage and repair, low dose/low dose rate effects, and non-ionising radiation. The second theme concerned areas where radiobiological information was important to the topic per se, and included symposia on food irradiation, diagnostic imaging, environmental radiation, radiotherapy, and the oxygen effect. All of these are areas where up to date radiobiological knowledge can be usefully applied. The environmental symposium involved a joint session with an international workshop on bioindicators and was preceded by a plenary lecture from Dr N Priest of the NRPB.

New Devel Fundam Appl Radiobiol

Mothersill

Science & Math

This is one of a series of books which aim to provide overviews of the current state of the art by specialists actively working in the field. The editors aim to focus on the borderline of our knowledge by presenting innovative results and controversial ideas. Some of the topics covered are cytochrome P-450 dependent pathways of the biosynthesis of steroid hormones, the structure and function of adrenal mitochondrial cytochrome P-450 and microbial steroid hydroxylating enzymes in glucocorticoid production.

Molecular Mechanisms of Adrenal Steroidogensis and Aspects of Regulation and Applicaion (Frontiers in Biotransformation Volume 3)

Biological Sciences

This volume starts with a substantial overview of the occurrence of cytochrome P-450 in bacterial species, considering historical aspects and especially describes the properties, distribution and diversity of bacterial cytochromes P-450. The book underlines our very different levels of knowledge of several bacterial cytochromes P-450, including specific cytalytic activities and spectral evidence on the one hand and detailed data on molecular structure and function of other species on the other. The first chapter describes the hydrocarbon inducible cytochrome P-450 from acinetobacter calcoaceticus. This microganism has been intensively studied in the past as a model for the assimilation of long chain n-alkanes by bacteria. The catalytic activity of yeast cytochrome P-450 exceeds those of mammalian cytochromes P-450 by 2-3 orders of magnitude. Up to now the reasons for this large difference are not known. But detailed knowledge of the alkane hydroxylating cytochrome P-450 as it is summarized in chapter 3 by Muller, Schunck and Kabgel could be useful for solving this question as it is important for the use of cytochromes P-450 in biotechnology. In chapter 4, Yoshida and Aoyama deal with details of the molecular mechanism of cytochrome P-450 which was isolated and purified from saccharomyces cerevisiae and identified as lanosterol 14x-demethylase. By means of reconstitution experiments, the authors prove that the fungicidal activity of azole antifungal agents originates from its interaction with cytochrome P-450. This form is the only cytochrome P-450 which is widely distributed in eukaryotes with essentially the same function, that is, 14x-demethylation of lanosterol and cholesterol. Therefore, knowledge about the properties of this monoxygenase is not only of practical interest because of its target function for antifungal agents, but it may also be an important object for studying the evolution of cytochrome P-450. The review by Hudnik-Plevnik and Breskvar contains data about cytochrome P-450 in rhizopus nigricans, one of the biotechnologically important micro-organisms.

Microbial and Plant Cytochromes P-450: Biochemical Characteristics Genetic Engineering and Practical Implications (Fronteirs in Biotransformation Volume 4)

This text attempts to bridge the disciplinary gap between the study of language and literacy, and the study of social theory and critical pedagogy. Topics covered include contemporary, social and cultural approaches to literacy, and key aspects of discourse studies and sociolinguistics.

Social Linguistics and Literacies (Critical Perspectives on Literacy and Education)

Politics & Social Sciences

James Paul, Gee

Social Sciences

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