Blood stem cell transplantation has become an established therapeutic option in the treatment of malignant diseases. At the same time molecular therapeutic approaches (i.e. gene therapy) are promising alternatives to the classical treatment of cancer. The proceedings give an overview of the biology of hematopoietic progenitor cells, peripheral stem cell transplantation in patients with hematological malignancies, recent developments in molecular diagnosis and gene therapeutic concepts, and show that successful future developments require cooperative research connecting basic science with clinical application.

Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy (Recent Results in Cancer Research)

Medical Books

S Springer

Medicine

Springer, Berlin / New York

The Symposium "Esophageal Carcinoma - State of the Art" has aroused very great interest. The numerous enquiries have caused us to publish the congress proceedings in the present volume. Particular attention was paid to current topical problems. One of the areas on which the present volume focuses is the epidemiol ogy and pathology of esophageal adenocarcinoma. Compared to squamous epithelial carcinoma, this is increasing in incidence in Europe. Modern diagnostic methods are described such as laser induced fluorescence spectroscopy or the optical coherence endo scopic technique. The latter enables normal mucosa to be distin guished from dysplastic or malignant lesions, in contrast to con ventional endoscopy. As in other tumors of the gastrointestinal tract, neoadjuvant therapy is becoming of increasing importance. Since the indication crucially depends on the tumor stage, two contributions deal with postoperative staging, with the diagnostic reliability of the individual techniques and new methods such as endoluminal MRI. There is no doubt that neoadjuvant chemo therapy is indicated in tumors which are irresectable and in tumor stages in which resectability is uncertain. However, to what extent it should also be applied in the resectable stage will be discussed in the individual contributions both for adenocarci noma and for squamous epithelial carcinoma. In the meantime, surgical treatment of esophageal carcinoma has been largely stan dardized. Differences with regard to radicality are still found in the extent of lymphadenectomy, especially in inclusion of cervi cal lymph nodes.

Esophageal Carcinoma: State of the Art

Lange, J.

Siewert, J. R., eds

Health, Fitness & Dieting

Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data. This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.

Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins (Results and Problems in Cell Differentiation)

Science & Math

Dos Remedios, C. G.

Thomas, D. D., eds

Biological Sciences

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