Using real examples from oncology trials, but keeping it simple, this concise resource explains the basic principles of medical statistics so that you can better appraise clinical trial results. Key concepts covered in this book include: * hypothesis testing * Kaplan-Meier curves and other graphic representations of data * calculating the power of a study * the stopping rules for efficacy and futility. 'Fast Facts: Medical Statistics' is aimed at all clinicians, clinical scientists, medical writers and regulatory personnel who need a better understanding of the statistical terms and methods used in the planning of studies and the analysis of clinical trial data. If you have ever wanted to know what a type I error is, how an odds ratio is calculated or what a forest plot is really all about, then this is the book for you. Contents: * Statistical inference * Analysis of time-to-event endpoints * Power and sample size * Multiplicity * Interim analysis * Modeling * Graphical methods

Fast Facts: Medical Statistics

Medical Books

RICHARD

Administration & Medicine Economics

S. Karger Publishing

A Karger 'Publishing Highlights 1890–2015' title This handbook takes the reader through the entire field of pediatric thrombosis and hemostasis. An introductory section concisely explains the complex pathophysiology of hemostasis and thrombosis. The chapters that follow include practical, evidence-based information on the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children. Special features include practical clinical algorithms and appendices that cite normal laboratory reference ranges, as well as recommended dosages of blood products and major hemostatic agents. A stand-alone chapter is dedicated to developmental hemostasis and bleeding in the neonate. A chapter on antithrombotic therapy in children gives succinct information on the old and new anticoagulants, antiplatelet drugs and thrombolytic agents. Written and reviewed by international experts in the field, this handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and clotting disorders, including general and specialist pediatricians (in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists), hematologists/oncologists (pediatric and adult), as well as medical trainees, nurses, nurse practitioners and pharmacists.

SickKids Handbook of Pediatric Thrombosis and Hemostasis

V.S. Blanchette

Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty. This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.

Cancer and Aging: From Bench to Clinics (Interdisciplinary Topics in Gerontology, Vol. 38)

M. Extermann

Medicine

Excessive daily sleepiness associated with obstructive sleep apnea is a multifaceted complaint that usually involves disabling symptoms. Despite being a common complaint, best practice regarding the management of patients is not well defined, and failure to recognize the severity of the effects of symptoms on quality of life results in underdiagnosis, preventing patients from receiving adequate treatment. 'Fast Facts: Excessive Daily Sleepiness Associated with Obstructive Sleep Apnea' discusses the difficulties in formulating a single definition of excessive daily sleepiness that appropriately considers the experiences and features of daytime sleepiness, alongside an up-to-date overview of how to accurately assess patients, and ensure effective management and support. Table of Contents: * Epidemiology and etiology * Clinical features and diagnosis * Management * Patient impact and support

Fast Facts: Excessive Daytime Sleepiness Associated with Obstructive Sleep Apnea

Walter, T.

McNicholas

Kallweit

Lammers

Gert Jan

Steier

Joerg

This publication presents currently available evidence about the extent to which dermatological diseases may, through their own nature as well as a multitude of comorbidities and their important interactions with social life, impair the life course of patients. Divided into four parts, the book starts with a brilliant introduction that highlights the importance of a life course approach in medicine from a medical as well as from a psychosocial point of view. The second part provides a basic presentation of the theoretical aspects of life course research and, more specifically, to the concepts of allostatic load and cumulative life course impairment (CLCI). The third part examines concepts related to CLCI, such as the quality of life in dermatology or the major life changing decisions influenced by dermatological diseases. The book concludes with an in-depth investigation of specific diseases where the concept of CLCI strikes as particularly relevant. The new and innovative evidence presented in this publication makes it essential reading to anyone who has to take social implications of skin diseases into account in their decision making: dermatologists, allergologists, pediatricians and general practitioners as well as researchers in medical sociology or opinion leaders in public health.

Dermatological Diseases and Cumulative Life Course Impairment (Current Problems in Dermatology, Vol. 44)

Health, Fitness & Dieting

M.D. Linder

Psychology & Counseling

The relation between nutrition and growth in children is one of the key concerns of pediatric health that touches a multitude of specialties. Exchanging concepts and knowledge between professionals of all the different disciplines involved is thus crucial to facilitate research and interdisciplinary clinical collaborations. The present 'Yearbook on Nutrition and Growth' is unique in its concept: The contributing editors of each chapter have chosen recent journal articles that have the most potential in relation to the topic of their chapter. Providing the practicing physician with succinct editorial comments, the editors also evaluate the clinical importance of each article and discuss its application. This yearbook is a valuable resource for pediatricians interested in the subspecialties of nutrition, endocrinology and gastroenterology, but also for pediatric nutritionists and dieticians, and other health professionals involved in the care of children.

Nutrition and Growth: Yearbook 2014 (World Review of Nutrition and Dietetics, Vol. 109)

B. Koletzko

Basic Sciences

The fifth revised edition of this highly successful book presents the most extensive enhancement since Using and Understanding Medical Statistics was first published 30 years ago. Without question, the single greatest change has been the inclusion of source code, together with selected output, for the award-winning, open-source, statistical package known as R. This innovation has enabled the authors to de-emphasize formulae and calculations, and let software do all of the ‘heavy lifting’. This edition also introduces readers to several graphical statistical tools, such as Q-Q plots to check normality, residual plots for multiple regression models, funnel plots to detect publication bias in a meta-analysis and Bland-Altman plots for assessing agreement in clinical measurements. New examples that better serve the expository goals have been added to a half-dozen chapters. In addition, there are new sections describing exact confidence bands for the Kaplan-Meier estimator, as well as negative binomial and zero-inflated Poisson regression models for over-dispersed count data. The end result is not only an excellent introduction to medical statistics, but also an invaluable reference for every discerning reader of medical research literature.

Using and Understanding Medical Statistics

Politics & Social Sciences

D.E. Matthews

V.T. Farewell

Social Sciences

With the intention of improving the rate, quality, and stability of orthodontic tooth movement, those in the field are now moving toward accomplishing this 'acceleration' with minimally or non-invasive methods. New procedures have been widely tested in humans, animal models, and in vitro. While interest is growing both in the industry and at the clinical level, the understanding of the biology is limited. Considering that a simple increase in force will result in tooth morbidity and arrest of the tooth migration, a multi-disciplinary approach is critical for success. This publication brings together multi-disciplinary expertise on a wide variety of processes related to and involved in orthodontic tooth movement. The premise is that, by better understanding the biological structures and the mechanism through which they respond to biomechanical forces, one can get a better assessment of the 'acceleration'. This work presents research aimed at an improved understanding of conventional and accelerated orthodontic tooth movement from a biological perspective and will be of great value to clinicians, researchers, academics, and students.

Tooth Movement (Frontiers of Oral Biology, Vol. 18)

A. Kantarci

Dentistry

This patient booklet was written for women undergoing treatment for gynaecological cancer. It aims to provide an understanding of the possible side effects of treatments, with a particular focus on sexual health, intimate relationships, and reproductive wellbeing. The content includes practical advice for managing side effects and information on pharmaceutical and non-pharmaceutical therapies. The booklet also includes links to external resources, further information and support options. This unique resource, developed with input from women who shared their experiences, will help women navigate the physical and emotional complexities of gynaecological cancer and its treatment.

Fast Facts for Patients: Sexual and Reproductive Health After Gynaecological Cancer

BRIGGS

Paula

Mohamed

Mehasseb

Acute pancreatitis (AP) is one of the most common disorders of the gastrointestinal tract to result in hospitalization. Although most patients with AP will experience an uneventful disease course, those that develop moderate-to-severe AP can be challenging to manage. Rapid recognition, accurate diagnosis and prediction of severity, together with appropriate treatment, are therefore key in achieving the best outcomes for patients and for preventing subsequent episodes of AP.Written by two pancreatologists with extensive experience of managing patients with AP as well as in clinical research, 'Fast Facts: Acute and Recurrent Pancreatitis' provides a comprehensive, evidence-based guide to: - The pathophysiology and etiology of AP - Fundamentals of diagnosis - Predicting the likely severity of an episode of AP - Monitoring and managing complications in the early and later stages of disease - Preventing recurrence This book will be of interest to all those who may be involved in the care of patients with AP, including internal medicine specialists, gastroenterologists, intensive care specialists, surgeons and endoscopists. Contents: * Pathophysiology * Epidemiology and etiology * Diagnosis * Prognosis * Definitions for complications and severity classification * Early management * Management of symptomatic collections * Management of other local complications * Preventing recurrence and monitoring for late complications after acute pancreatitis

Fast Facts: Acute and Recurrent Pancreatitis

Löhr

Matthias

Enrique

de-Madaria

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Books by S. Karger Publishing