Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: • Essential thrombocythemia (ET) – characterized by increased platelet count • Polycythemia vera (PV) – characterized by excessive production of red blood cells • Primary myelofibrosis – a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.

Myeloproliferative Neoplasms (Fast Facts)

Medical Books

Mesa, Ruben A

Harrison, Claire N.

Medicine

S Karger Ag

Psychosis affects nearly 50% of patients with Parkinson's disease (PD). It is a major therapeutic challenge, as a balance needs to be found between the PD medications that can exacerbate psychotic symptoms and the antipsychotics that may worsen motor function. Focusing on the most common side effects of PD medications, namely visual hallucinations and delusions, this highly readable handbook will increase readers' awareness of: * the various presentations of psychosis in PD * modifiable risk factors * prescribing that balances the benefits and potential harms. Detailed case studies and evidence-based guidance for practical application make 'Fast Facts: Psychosis in Parkinson's Disease' an invaluable resource for all healthcare professionals responsible for the outpatient care of patients with PD, including neurologists, psychiatrists, geriatricians, psychiatric nurse practitioners, specialist PD nurses and primary care providers.

Fast Facts - Psychosis in Parkinson's Disease: Finding the Right Therapeutic Balance.

Friedman, Joseph H.

Ballard, Clive

Cutaneous T-cell lymphoma (CTCL) has been described as a 'great mimicker'. The correct diagnosis hinges on effective collaboration between clinicians and pathologists to correlate pathological and clinical findings. The patient's history, lesion description and diagnostic work-up will help the pathologist interpret the histopathology, whilst the clinician’s diagnosis is aided by a clear understanding the terminology used in the pathology report. The treatment of early and advanced mycosis fungoides and its variants is potentially lifelong, with patients typically cycling among treatments, interspersed with periods of expectant therapy providing palliation and symptomatic relief. Effective management requires knowledge of the wide range of options, how they are used, and their side-effect profile, in order to tailor treatment to the individual patient. ' Fast Facts: Cutaneous T-Cell Lymphoma' is designed to help primary care providers, dermatologists, and oncologists to communicate effectively with pathologists in the diagnosis of this chronic condition, aided by over 100 superb clinical and pathological images, and to provide tailored long-term care for their patients. This concise, practical handbook will ensure clear communication with respect to the clinical presentation, histopathology, immunophenotyping and treatment of: • early and advanced mycosis fungoides and its variants • Sézary syndrome • other non-mycosis fungoides CTCLs. It is essential reading for pathologists, non-specialist clinicians and dermatology and oncology trainees.

Cutaneous T-cell Lymphoma (Fast Facts)

Haun, Paul L.

Scarisbrick, Julia J.

'Fast Facts: Advanced Cutaneous Squamous Cell Carcinoma' is for people who have or may have advanced cutaneous squamous cell carcinoma. It aims to help patients, and people close to them, understand the condition so they can have better discussions with the cancer team. Decisions about treatment and next steps are highly individual. They will depend on the site and features of the person's cancer as well as their general health. With its clear text and diagrams, this booklet can help the patient understand how the cancer develops and the tests and treatments that may be recommended. And with boxes and prompts for the reader's own notes and questions, 'Fast Facts: Advanced Cutaneous Squamous Cell Carcinoma' can become a truly personalized resource.

Advanced Cutaneous Squamous Cell Carcinoma for Patients and Their Supporters: Information + Taking Control = Best Outcome (Fast Facts)

Arron, Sarah T.

Glioblastoma: New Molecular Concepts Pave the Way for Advances in Diagnosis and Treatment. (Fast Facts)

Brandner, Sebastian

Mcnamara, Mairéad

Thust, Stefanie C.

'Light therapy' is established worldwide as the treatment of choice for seasonal affective disorder. It is also successfuly used in nonseasonal depression, as well as for many other psychiatric and neurologic illnesses, and in sleep medicine. ‘Wake therapy’ is the fastest antidepressant known. Imaging studies show that both methods share neurobiological substrates with antidepressants, but act much faster. 'Chronotherapeutics' – the combination of light and wake therapy – achieves rapid results and, by reducing residual symptoms, also minimises relapse. Written by three prominent clinical and research experts in biological rhythms, this manual aims to broaden knowledge and practical application of these non-pharmacologic interventions for bipolar and unipolar disorders. Clinical understanding is deepened by an explanation of the circadian timing system and sleep regulatory mechanisms which underlie the novel treatment strategy. The step-by-step guide and description of the interventions in centers throughout the world provides clear hands-on instructions, supported by a solid body of clinical research. The first edition of 'Chronotherapeutics for Affective Disorders' has kindled a network of psychiatrists and psychologists who are actively introducing these treatments for their inpatients and outpatients. This manual is also essential reading for primary care physicians, sleep medicine specialists and health care administrators.

Chronotherapeutics for Affective Disorders: A Clinician's Manual for Light and Wake Therapy

Health, Fitness & Dieting

A. Wirz-Justice

F. Benedetti

Michael Terman

Diseases & Physical Ailments

Cleft lip and palate is a complex, multifactorial and relatively common craniofacial disorder, which arises because of disrupted facial development in the embryo. The manifestations of this condition can be life-long and associated with significant morbidity. In the last decade, progress has been made in our understanding of how clefts of the lip and palate arise in human populations, and laboratory studies are beginning to elucidate the molecular mechanisms that control development of the lip and palate. In addition, advances in surgical and medical care, and long-term rehabilitation are improving outcome and quality of life for affected individuals. Written by international experts in their respective fields, this publication covers in detail the epidemiology and genetic basis of cleft lip and palate, the developmental biology of lip and palate formation and provides current concepts in the management of patients affected by this condition. Thus, the book provides a contemporary overview of the epidemiology, aetiology and treatment of cleft lip and palate, and will be of use to a wide range of individuals, including students, biologists and clinicians, who have an interest in this subject.

Cleft Lip and Palate: Epidemiology, Aetiology and Treatment (Frontiers of Oral Biology)

Science & Math

Cobourne M T Ed

Biological Sciences

Despite the various advantages of home dialysis compared to in-center hemodialysis, only a fraction of patients in Japan currently opt for peritoneal dialysis or home hemodialysis. However, considerable advances in research and technical improvements have been made lately, advancing the practice of home dialysis therapy in Japan. Japanese research is well-known for its ingenuity and creative energy with regard to the development of new machines and systems for dialysis. New insights regarding peritoneal dialysis and home hemodialysis are presented in the publication at hand: Contributions by leading Japanese experts discuss topics such as educational methods, techniques, tools, novel systems and organization of patients. The book will be of great interest to clinical physicians involved in dialysis care; Moreover, the expertise collected in this volume may contribute to the advancement of home dialysis therapy in a global context.

Home Dialysis in Japan: Contemporary Status (Contributions to Nephrology)

Engineering & Transportation

Suzuki H Ed

Engineering

Obesity continues to be a major problem for global public health, affecting not only adults, but increasingly also adolescents and even young children. Moreover, obesity and diabetes are no longer limited to wealthy societies: rates are also rising in low- and middle-income countries. Summarizing some of the key issues in obesity treatment and prevention, this publication promotes novel and interdisciplinary approaches and explores cutting-edge ideas that span child development, nutrition, behavioral sciences, economics, geography and public health. Contributions suggest a sequence of steps that may result in new ways to address obesity at the personal as well as at the population level: First, a clear understanding of who becomes obese, where, and for what reason is needed. Second, the likely contributions to overeating by the brain, biology, economics and the environment need to be identified. Then, based on the understanding of disease etiology and its distribution by geography and by social strata, targeted yet comprehensive strategies for obesity prevention and treatment for both individuals and groups need to be developed.

Obesity Treatment and Prevention: New Directions (Nestle Nutrition Institute Workshop)

Allied Health Professions

Vitamin A plays a key role among the vitamins essential for healthy growth and development. Vitamin A deficiency disorders (VADD) are therefore an important part of general malnutrition that in the majority of cases leads to failure to thrive and underweight. Moreover, apart from adverse effects on health and survival in general, VADD can also lead to blindness, called xerophthalmia, and are also frequently accompanied by various infections. Last but not least, it has become evident that even mild degrees of VAD (and all other forms of nutritional deficiencies) have important adverse implications for health and are thus much more widespread than previously assumed. This publication systematically covers detailed and up-to-date information on every relevant aspect of VADD, with particular emphasis on providing an outline of their setting, nature, and significance. In addition to cutting-edge scientific information, the latest available data on the global occurrence of VAD from the World Health Organization is also included.

Manual on Vitamin a Deficiency Disorders Vadd (World Review of Nutrition and Dietetics)

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Books by S Karger Ag