The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. 
Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition.
Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.

Nicotinic Acetylcholine Receptors: From Molecular Biology to Cognition

Science & Math

CHANGEUX, JEAN-PIERRE

Edelstein, Stuart J.

Biological Sciences

Odile Jacob

Lettre à tous ceux qui aiment l'école

FERRY, Luc

Mourir de dire

CYRULNIK, BORIS

Le sommeil et le rêve (Sciences) (French Edition)

Reference

Jouvet, Michel

Foreign Language Study & Reference

Le Gene Egoiste

Literature & Fiction

RICHARD DAWKINS

Contemporary

Régulation et crises du capitalisme

Aglietta, Michel

Editeur : Editions Odile Jacob Date de parution : 1998 Description : In-8, 169 pages, souple, occasion, bon état. Envois quotidiens du mardi au samedi. Les commandes sont adressées sous enveloppes bulles. Photos supplémentaires de l'ouvrage sur simple demande. Réponses aux questions dans les 12h00. Librairie Le Piano-Livre. Merci. Please let us know if you have any questions. Thanks

Le petit livre de la ménopause (OJ.SANTE QUOTID) (French Edition)

Health, Fitness & Dieting

Chaine, Caroline

Women's Health

Editeur : Odile Jacob Date de parution : 2001 Description : In-8, 764 pages, broché, occasion, très bon état. Envois quotidiens du mardi au samedi. Les commandes sont adressées sous enveloppes bulles. Photos supplémentaires de l'ouvrage sur simple demande. Réponses aux questions dans les 12h00. Librairie Le Piano-Livre. Merci. Référence catalogue vendeur: 57605. Please let us know if you have any questions. Thanks

Histoire de France (French Edition)

History

Marc Ferro

Europe

L'Enseignement du fait religieux dans l'école laïque

Debray, Régis

Lang, Jack

Génétique du péché originel: le poids du passé sur l'avenir de la vie

Christian de Duve

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Books by Odile Jacob