Rekem: A Federmesser Camp on the Meuse River Bank (Acta Archaeologica Lovaniensia Monographiae, 10)

Politics & Social Sciences

De Bie, Marc

Caspar, Jean-Paul

Bie, Marc De

Archaeology

Leuven Univ Pr

Molecular Genetic Analysis of the Glypicans, a Family of Cell Surface Heparan Sulfate Proteoglycans (Acta Biomedica Lovaniensia, 217)

Science & Math

Veugelers, Mark

Biological Sciences

Design & Experimental Evaluation of Allergen-Derived Peptides for Specific Immunotherapy of Allergic Diseases (Acta Biomedical Lovaniensia, 227)

Health, Fitness & Dieting

Wu, Bo

Diseases & Physical Ailments

Na+ Reabsorption and Cl- Secretion Across Cultured Renal Epithelia (A6: Effects of Hypotonicity & External Cations (Acta Biomedica Lovaniensia, 245)

Jans, Danny

Evolution

In modern-day medicine, the use of intravascular catheters has become unavoidable. In the United States, hospitals and clinics purchase more than 150 million intravascular devices each year of which more than 5 million are central venous catheters (CVC). They are used for the administration of medication (antibiotics, chemotherapy), fluids and nutrition and for haemodialysis. Venous as well as arterial catheters (AC) also have become indispensable for the continuous monitoring of vital parameters in the intensive care unit (ICU). However, their use does not come without risk. It puts patients at danger for iatrogenic mechanical, thrombotic and, most importantly, infectious complications. 
Catheter-related infection (CRI) can have serious consequences by inducing catheter-related bloodstream infection (CRBSI) with an important increase in morbidity and sometimes mortality. The magnitude of the problem is immense (an estimated 250,000 CVC-associated bloodstream infections per year in the USA alone). After several decades of clinical experience with the use of intravascular devices many unanswered questions still remain regarding the prevention, diagnosis and treatment of CRI. The intention of the research described in this manuscript was to answer several of these questions. In a first phase, based on our clinical experience and an extensive literature review, an attempt was made to extract some of the clinically more relevant questions. Six of them were retained through the design of 4 clinical trials and a literature analysis answers were sought after.

Intravascular Catheter-Related Infections: A Clinical Focus on Prevention, Diagnosis & Treatment (Acta Biomedica Lovaniensia, 299)

Reference

Rijnders, Bart

Encyclopedias & Subject Guides

This is a Ph.D. dissertation. In this thesis attention will be focuses on the mechanisms by which growth hormone and insulin modify some major metabolic pathways, in light of their opposite effects on outcome of critical illness. Chapter 1 comprises a brief overview of the clinical presentation of critical illness and its endocrine aspects, together with an introduction to the insulin-like growth factor axis and liver function during critical illness. A selection of highly regarded review articles will help the reader gain insight into these matters. For reasons of conciseness original publications were left out of the introduction. A statement on the general hypothesis and the study objectives closes the introductory chapter. In Chapter 2 reports of four original, experimental studies, either published, in press or in submission, will be presented. 
This chapter includes a study in which we examined the effect of growth hormone on the sepsis-induced modulation of the hepatic bile transporter system. The chapter also encompasses the studies of the effects of intensive insulin therapy on glucose and lipid metabolism during critical illness, together with its modulation of the growth hormone-dependent somatropic axis. Chapter 3 will be dedicated to a general discussion of the findings in the light of the existing literature, citing the original publications. This thesis should provide a tool to discover the fascination of endocrine disease during critical illness.

Mechanisms of Growth Hormone & Insulin-Induced Alterations in Metabolism During Critical Illness (Acta Biomedica Lovaniensia, 302)

Medical Books

Mesotten, Dieter

Medicine

Assessment Of Human Cerebral Ischemia Using Magnetic Resonance Imaging Techniques (Acta Biomedica Lovaniensia)

Thijs, Vincent

Genetic Analysis Of Herpesvirus Entry Receptors And Host Susceptibility To Herpes Simplex Virus Infection (ACTA Biomedica Lovaniensia)

Struyf, Frank

Basic Sciences

This is a Ph.D. dissertation. The present thesis forms an integral part of the efforts to understand the molecular mechanisms and the biological and clinical significance of increased lipogenesis in tumor cells. In part I, it is explored whether the PI3-kinase/Akt pathway, a signal transduction cascade which is frequently dysregulated and constitutively activated in cancer cells, may contribute to increased lipogenesis. In part II, the authors have tried to gain more insight into the functional significance of tumor-associated lipogenesis by unraveling the nature and fate of newly synthesized lipids in cancer cells. To put these studies in a proper perspective, the authors will provide a more detailed overview of the present understanding of the mechanisms, the role and the clinical significance of increased lipogenesis in human cancer.

Increased Lipogenesis in Human Tumors: Mechanisms & Implications (Acta Biomedica Lovaniensia)

Sande, Tine Van De

This is a Ph.D. dissertation. The aim of this thesis was to understand the role of 1,25(OH)2D3 and other steroid hormones in the regulation of active duodenal calcium absorption. To achieve this aim, the authors analyzed active duodenal calcium absorption at molecular and functional level. Contents include: Introduction: Calcium, The vitamin D endocrine system, Calcium (re)absorption, Active calcium absorption, vitamin D independent mechanisms; Aims and Scope of the study; Vitamin D dependent active duodenal calcium absorption; Active calcium absorption throughout the female reproductive cycle; The contribution of altered active absorption to the pathogenesis of glucocorticoid-induced bone loss; Discussion; Summary; Perspectives.

Duodenal Calcium Absorption & Steroid Hormones: A Transgenic Mice Study (Acta Biomedica Lovaniensia)

Cromphaut, Sophie Van

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