FROM THE PUBLISHER (Alfred A. Knopf): Immediately following the revolutionary discovery of the structure of DNA by James D. Watson and Francis Crick in 1953, the world of molecular biology was caught up in a gold rush. The goal: to uncover the secrets of life that the newly elucidated molecule promised to reveal. Genes, Girls, and Gamow is James Watson's report on the amazing aftermath of the DNA breakthrough, picking up where his now classic memoir, The Double Helix, leaves off. Here are the collaborations and collisions of giants, not only Watson and Crick themselves, but also legions of others, including Linus Pauling (the greatest chemist of the day), Richard Feynman (the bongoplaying cynosure of Caltech), and especially George Gamow, the bearlike, whiskeywielding Russian physicist, who had turned his formidable intellect to the field of genetics; with Gamowan irrepressible prankster to bootWatson would found the legendary RNA Tie Club. But Watsonat twentyfive already the winner of genetic research's greatest jackpotis obsessed with another goal as well: to find love, and a wife equal to his unexpected fame. As he and an international cast of roguish young colleagues do important research they also compare notes and share complaints on the scarcity of eligible mates. And amid the feverish search for the role of the then still mysterious RNA molecule, Watson's thoughts are seldom far from the supreme object of his desire, an enthralling Swarthmore coed who also happens to be the daughter of Harvard's most eminent biologist. Part scientific apprenticeship, part sentimental education, Genes, Girls, and Gamow is a penetrating revelation of how great science is accomplished. It is also a charmingly candid account of one young man's full range of ambitions.

Genes, Girls, and Gamow: After the Double Helix

Biographies & Memoirs

Watson, James D.

Professionals & Academics

Cold Spring Harbor Laboratory Press

With an reliable, accessible, and intriguing introduction to modern, genome-centered biology from its foremost practitioners, Recombinant DNA: Genes and Genomes explores core concepts in molecular biology through the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA.

Recombinant DNA: Genes and Genomes - A Short Course, 3rd Edition

Science & Math

James D. Watson

Richard M. Meyers

Amy A. Caudy

Jan A. Witkowski

Biological Sciences

The first edition of Jim Watson's classic textbook Molecular Biology of the Gene appeared in 1965. This new edition, written with five new authors, has been brought fully up to date, and incorporates insights very recently derived from genome sequencing in a variety of organisms. The book is an authoritative and comprehensive survey of the fundamentals of molecular biology, from basic mechanisms to the elaborate role of gene regulation in embryonic development and evolution. Although updated, the twentyone chapters of the new edition retain the distinctive and celebrated features of the original work, including introductory chapters on the history of genetics and molecular biology and an emphasis throughout on the chemical underpinnings of molecular biology. The new team of authors brings to this edition awardwinning teaching experience and outstanding research achievements. By revealing the intellectual framework and experimental approaches that made new discoveries in the field possible, the new edition highlights the significance of the molecular approach for all of biology.

Molecular Biology of the Gene, Fifth Edition

Computers & Technology

Software

Though completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson’s classic book, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline. Mendelian View of the World, Nucleic Acids Convey Genetic Information,The Importance of Weak Chemical Interactions, The Importance of High Energy Bonds, Weak and Strong Bonds Determine Macromolecular Interactions, The Structures of DNA and RNA, Genome Structure, Chromatin and the Nucleosome, The Replication of DNA, The Mutability and Repair of DNA, Homologous Recombination at the Molecular Level, Site-Specific Recombination and Transposition of DNA, Mechanisms of Transcription 13 RNA Splicing, Translation, The Genetic Code, Transcriptional Regulation in Prokaryotes, Transcriptional Regulation in Eukaryotes, Regulatory RNAs, Gene Regulation in Development and Evolution, Genomics and Systems Biology, Techniques of Molecular Biology, Model Organisms. Intended for those interested in learning more about the basics of Molecular Biology.

Molecular Biology of the Gene, Sixth Edition

The central question in neurobiology is: How does the brain work? At the beginning of the 1980s, armed with the new techniques of recombinant DNA and monoclonal antibodies, molecular biologists began to approach some aspects of this question without being intimidated by the formidable facts of electrophysiology or neuroanatomy. In the past decade these first steps toward the last frontier of biology have quickened and lengthened. Talented investigators have brought to the field expertise and imagination derived from other branches of biology and computer science. These have been applied to the study of nerve cell growth and differentiation, signal reception and transduction, and networked cellular interactions in such fundamental processes as vision, olfaction, learning, memory, and motor control. Over 100 outstanding scientists were invited to Cold Spring Harbor's 55th annual Symposium to present their latest ideas and data. In May 1991, their papers were published in this volume of the most prestigious book series in biology. Symposium LV presents current neurobiology in all its dramatic diversity and is an unrivaled resource for workers in this field.

Cold Spring Harbor Symposia on Quantitative Biology: The Brain: 55 (Cold Spring Harbor Symposia on Quantitative Biology (Hardcover))

Cold Spring Harbor Laboratory

Book by Cold Spring Harbor Laboratory

The Cell Cycle: Cold Spring Harbor Symposia on Quantitative Biology, Volume LVI

So much has been learned about the surface of cells that it can almost be counted as an organelle. The surface has been revealed as a complex assembly of proteins, highly mobile in time and space, with overlapping activities and shared structural motifs. The locations of their genes and the untangling of their functions are major challenges being tackled by laboratories worldwide. The 57th annual Cold Spring Harbor Symposium brought together over 80 leading investigators to discuss data and ideas on receptor-ligand interactions, membrane organization, signal transduction, peptide transport, cell adhesion, and the regulation of developmental processes. Studies in molecular and cell biology, embryology, neurobiology, and immunology were presented. This volume of collected papers from the Symposium, like its predecessors in this most prestigious series, provides a wide-ranging, eclectic review of a topic central to the understanding of cell structure and function.

Sym Vol 57 Cell Surface (C) (Symposium)

Over 80 investigators provide a panoramic account of how cells control and repair the folding of newly synthesized proteins and transport them correctly to membranes, mitochondria and other cellular addresses. This volume should be useful to all cell biologists. It also provides in-depth background information for specialists in synaptic function, cell movement, antigen presentation and other cellular functions to which protein kinesis is vital.

Protein Kinesis: The Dynamics of Protein Trafficking and Stability: Cold Spring Harbor Symposia on Quantitative Biology, Volume LX (Cold Spring Harbor Symposia on Quantitative Biology (Hardcover))

Protein Kinesis: The Dynamics of Protein Trafficking and Stability: Cold Spring Harbor Symposia on Quantitative Biology, Volume LX

Replication of Mammalian Parvoviruses

D. C. Ward

Evolution

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Books by Cold Spring Harbor Laboratory Press