Effects of Drugs on Clinical Laboratory Tests

American Association for Clinical Chemistry

This updated edition of the classic, best-selling textbook -- including new chapters on methods validation, benzodiazepines, and GHB -- is ideal for the classroom and the reference shelf. Since the publication of the first edition in 1999, Principles of Forensic Toxicology has been used extensively for teaching students taking a one-semester course in forensic toxicology. It has also proven to be an invaluable reference for laboratorians. The first section provides an introduction to postmortem forensic toxicology, human performance forensic toxicology, forensic drug testing, and pharmacokinetics and pharmacodynamics. The second section is devoted to analytical principles, including both theory and applications. Methodologies covered include specimen preparation, spectrophotometry, chromatography, immunoassay, mass spectrometry, and methods validation. The third section covers commonly encountered analytes, including alcohol, benzodiazepines, GHB, miscellaneous central nervous system depressants, opioids, cocaine, marijuana, amphetamines/sympathomimetic amines, hallucinogens, anticonvulsants, antiarrhythmics, antidepressants, neuroleptics, carbon monoxide/cyanide, inhalants, and metals.

Principles of Forensic Toxicology, Revised and Updated 2nd Edition

Medical Books

Levine, Barry, Ed.

Medicine

The final volume in a three-volume series focusing on the three phases of laboratory testing -- preanalytical (Volume 1), analytical (Volume 2), and postanalytical (Volume 3). With leading experts in their specialty areas as contributing authors, this series is truly one of a kind and the first to consider the entire testing process under one publication series. This three-volume series is designed to provide the laboratory community with the latest information on advances and developments in the handling of specimens prior to testing, in workstation consolidation, and in new methodologies and analytical systems as well as the expansion of point-of-care testing and the explosion of information technology. It presents the challenges and innovations that should be expected as the technology and our healthcare delivery systems evolve. - Volume 1 provides the reader with a comprehensive overview of healthcare and its impact on diagnostic services, the evolution of technology and testing services, workflow analysis, critical pathways and specimen processing, preanalytical laboratory information systems, and preanalytical instrumentation. - Volume 2 focuses on the use of technology, quality, and basic principles of instrumentation. Techniques and automated systems of all laboratory testing areas will be presented, including total laboratory automation and point of care - Volume 3 addresses quality assurance and quality control issues, verification and reporting of results, postanalytical laboratory information systems and telemedicine, biosensors, the virtual clinical laboratory and artificial intelligence, and clinical laboratories in the 21st century.

Clinical Diagnostic Technology - The Total Testing Process, Volume 3: The Postanalytical Phase (The Total Testing Process: Postanalytical Phase)

Kory M. Ward-Cook

Allied Health Professions

Incredibly, we have seen the first wave of retirement of the "baby boomer" generation of clinical chemists and laboratory scientists, with more to follow. This has created renewed employment opportunities in academia and clinical laboratories for our graduate students and postdoctoral fellows. Self-Assessment in Clinical Laboratory Science II was written as a supplement to Self-Assessment in Clinical Laboratory Science, Third Edition, to assist the next generation in passing certification examinations such as those offered in clinical chemistry, toxicology chemistry, and molecular diagnostics by the American Board of Clinical Chemistry. Although it has been eight years since the publication of the third edition of Self-Assessment in Clinical Laboratory Science, the content remains relevant. This new volume includes entirely new questions, written by 47 authors who are experts in their respective fields, and as with previous editions of Self-Assessment in Clinical Laboratory Science, the scope of topics has expanded to include new sections and subsections on coagulation, infectious disease serology, molecular virology, evidence-based medicine, analysis of body fluids, fertility and pregnancy, allergy, and hemoglobinopathies. Whether you are a student or practicing clinical scientist, this book will assist you in determining the gaps in knowledge that you may have, so that you can better study for certification examinations and remain current in this rapidly changing field.

Self-Assessment in Clinical Laboratory Science II

Wu, Alan H.B., Ed.

This workbook offers a step-by-step guide to applying the principles of evidence-based laboratory medicine (EBLM) in routine practice. The term "evidence-based" is increasingly becoming part of the language in the practice of clinical medicine, and in laboratory medicine. In laboratory medicine, it is also becoming clear that the "evidence" differs somewhat from that on which the specialty was founded. The foundation of laboratory medicine is an understanding of the molecular mechanisms that describe the pathology of disease, but in applying this knowledge to patient care the emphasis moves from understanding disease mechanisms to improving health outcomes. By applying EBLM to daily practice, laboratory professionals can 
<ul>
<li>Ensure appropriate use of tests at the requesting, decision-making, and application phases. </li>
<li>Make the business case for implementing new diagnostic tools and strategies that meet clinical needs. </li>
<li>Become full members of the clinical team and take an important role in implementing change.</li>
</ul> The key is understanding the question being asked-and then applying the A5 EBLM Cycle: Ask, Acquire, Appraise, Apply, Assess. This workbook walks readers through this process by providing a wide range of case studies that illustrate applications of EBLM in routine laboratory practice. Readers are then encouraged to record their own examples, consider how they might be addressed using the principles of EBLM, formulate research questions, and then follow those questions to their evidence-based solutions. Throughout the text, sidebars and exercises offer additional helpful information and highlight key concepts. Whether used alone or with colleagues, this workbook provides the knowledge and practice that will give readers confidence that they are indeed learning how to apply the best available scientific evidence to diagnostic challenges, and in the process, playing a central role in patient care.

Applying Evidence-Based Laboratory Medicine: A Step-By-Step Guide

Christopher P. Price

Robert H. Christenson

Joanne Lozar Glenn

New Second Edition! The Quick Guide to Coagulation Testing, Second Edition, is a quick-access, readily available pocket reference for health practitioners who order, collect, perform, or interpret hemostasis laboratory test results or administer hemostasis-related therapy. The Guide outlines the most common hemorrhagic and thrombotic conditions together with their respective assays to emphasize correct laboratory evaluation. Treatment discussions include the prophylactic and therapeutic application of non-biological, synthetic, and human blood-derived components to control bleeding, and the use of antithrombotics designed to prevent or resolve arterial and venous occlusions. The emphasis is on proper dosing and valid laboratory monitoring of hemostatic therapy. New to the second edition is a series of introductory-reference tables summarizing hemostasis assays for various conditions with their reference intervals, and when applicable, therapeutic ranges. The discussion of platelet and coagulation physiology is expanded, platelet function testing is detailed, and new antithrombotic therapies are described with therapeutic monitoring recommendations. All portions of the second edition have been enhanced to reflect current international practice standards.

Quick Guide to Coagulation Testing, 2nd Edition

Marisa B. Marques

George A. Fritsma

This third edition of the classic, best-selling textbook -- ideal for the classroom and the reference shelf -- includes new chapters on non-narcotic analgesics and antihistamines, as well as a number of updated chapters, including mass spectrometry, cannabis, and opioids. Since the publication of the first edition in 1999, Principles of Forensic Toxicology has been used extensively for teaching students taking a one-semester course in forensic toxicology. It has also proven to be an invaluable reference for laboratorians. The first section provides an introduction to postmortem forensic toxicology, human performance forensic toxicology, forensic drug testing, and pharmacokinetics and pharmacodynamics. The second section is devoted to analytical principles, including both theory and applications. Methodologies covered include specimen preparation, spectrophotometry, chromatography, immunoassay, mass spectrometry, and methods validation. The third section covers commonly encountered analytes, including alcohol, benzodiazepines, GHB, miscellaneous central nervous system depressants, opioids, cocaine, cannabis, amphetamines/sympathomimetic amines, hallucinogens, anticonvulsants, antiarrhythmics, antidepressants, antihistamines, neuroleptics, non-narcotic analgesics, carbon monoxide/cyanide, inhalants, and metals.

Principles of Forensic Toxicology, 3rd Edition

Barry Levine

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Books by American Association for Clinical Chemistry