Developmental biology is at the core of all biology. It deals with the processes by which the genes in the fertilized egg control cell behavior in the embryo and so determine its pattern, its form, and much of its behavior. The progress in developmental biology in recent years, with the applications of advances in cell and molecular biology, has been remarkable, and an enormous amount of information is now available. Designed for undergraduates, Principles of Development emphasizes basic principles and key concepts in developmental biology. Central to the authors' approach is the idea that development can best be understood by analyzing how genes control cell behavior. They have assumed that students have some basic familiarity with cell biology and genetics, but all key concepts, like the control of gene activity, are explained in the text. The authors have resisted the temptation to cover every aspect of development and have instead focused on those systems that best illuminate common principles, demonstrating throughout the book that there are universal principles governing development. The focus of the text is on vertebrates and Drosophila, but not to the exclusion of other systems, such as the nematode and the sea urchin, where they best illustrate a concept. An important feature of the book is the inclusion of the development of plants, a topic that has some unique and significant attributes but one that is usually neglected in other texts. Principles are presented clearly and numerous summaries are provided, both in words and in pictures. The illustrations in the book have been carefully designed and chosen to illustrate both experiments and mechanisms.

Principles of Development

Science & Math

Lawrence, Peter

Wolpert, Lewis

Beddington, Rosa

Jessell, Thomas

Meyerowitz, Elliot

Brockes, Jeremy

Biological Sciences

Oxford University Press

Based on a highly successful BBC series, A Passion for Science features thirteen informal conversations with eminent scientists--including physicists, molecular biologists, cancer researchers and astronomers--who speak with remarkable candor and good humor about the personal side of science: why they became scientists, what they find most rewarding about their work, and what it feels like to make a major discovery. Their answers are often startling. For instance, Nobel Laureate Abdus Salam reveals that he became a scientist by chance: he wanted to be a Civil Servant in Pakistan, but when World War II forced the cancellation of the Civil Servant exam, he went to Cambridge for advanced study in mathematics (to do better on the exam) and there became involved in particle physics. Stephen Jay Gould candidly assesses his scientific talents (not a particularly good deductive thinker nor mathematically inclined, but excellent at finding hidden connections) and he explains why this talent can solve a Dorothy Sayers mystery but not one by Agatha Christie. Tony Epstein, co-discoverer of the Epstein-Barr Virus (the first virus shown to cause cancer), recounts his reaction to seeing the virus for the first time ("I switched the microscope off...and I went out and walked round the block two or three times before I dared come back!") At once humorous, insightful, and inspiring, the stories these scientists tell offer a vivid portrait of scientific work, the day-to-day routine, and the moments that come once in a lifetime.

A Passion for Science

Richards, Alison

Of the great mysteries that face modern biologists, one of the most intriguing concerns the development of the microscopic embryo into exceedingly complex plants and animals--into roses and cacti, elephants and blue whales, apes and human beings. How does one cell give rise to so many millions of cells? How do they divide so as to form hearts, brains, eyes, and ears? Where in this pin-head-sized object is all this information encoded? Now, in The Triumph of the Embryo, British biologist Lewis Wolpert treats general readers to a lucid tour of embryology, offering the latest theories in this fascinating field. Like the best scientist-authors, Wolpert's writing is filled with rich and unusual examples, metaphors, and descriptions. Nor does he hesitate to move beyond his overall narrative to discuss the many issues it raises, such as aging, cancer, regeneration, and evolution. Readers discover why all calico cats are female; encounter a zebra-striped mouse and a fruit fly engineered to grow a leg out of its head; and consider such topics as why "cell death" is important in sculpting the body or why there seems to be a 110 year age barrier for the human body. Wolpert also traces the early history of the field, ranging from the original conflict of embryology raised by Aristotle right up to the belief (held even in the 19th century) that every human spermatozoa contained a fully-developed human being. And he illuminates modern embryology, sharing with readers a glimpse of the forefront of the field, including such groundbreaking concepts as CAMs (cell adhesion molecules) and induction (a mode of cell interaction whose discovery won the only Nobel Prize in embryology). To Wolpert, the triumph of the embryo is its ability to exploit with brilliant success a group of basic, elegant, and universal mechanisms in order to develop into a fully formed creature--no matter if it's to become a hydra or a horse. To readers, the triumph of The Triumph of the Embryo is Lewis Wolpert's ability to tell us all about it.

The Triumph of the Embryo

An age old mystery, the development of the microscopic embryo into exceedingly complex plants and animals--into roses and cacti, elephants and blue whales, apes and human beings--stands as one of the most fundamental and important questions facing modern biologists. How does one cell give rise to so many millions of cells? How do they divide so as to form hearts, brains, eyes, and ears? Where in this pin-head-sized object is all this information encoded? Now, in The Triumph of the Embryo, biologist Lewis Wolpert answers these and other questions in a lucid tour of embryology, which offers the latest theories in this fascinating field. Filled with rich and unusual examples, metaphors, and descriptions, Wolpert moves beyond his overall narrative to discuss the many issues it raises, such as aging, cancer, regeneration, and evolution. Readers discover why all calico cats are female; encounter a fruit fly engineered to grow a leg out of its head; and find out why there seems to be a 110 year age barrier for the human body. Clearly written and illustrated with striking examples, The Triumph of the Embryo offers a dazzling look at the marvels of modern biology.

How does a single cell develop into myriad different specialized cell types, control the organization of these different cells into tissues and organs, and ultimately form an unimaginably complex living organism like a human being? How is it possible for some adult animals, but not others, to regenerate fully functioning limbs? Answering these questions and many more in captivating detail, Principles of Development, Fifth Edition, introduces students to the fascinating field of developmental biology. It clearly and succinctly explains cutting-edge science and illustrates principles with a variety of custom-drawn figures, animations, and links to online movies that show development happening in real time. The authors consistently focus on the key principles of development--the underlying processes shared by diverse groups of organisms. This emphasis on principles provides a framework on which students can build a rich understanding of specific topics. Extensive pedagogical support materials, both in the book and online, make this text the complete package for students of developmental biology.

Tickle, Cheryll

Martinez Arias, Alfonso

Principles of Development is designed for undergraduates. The emphasis is on principles and key concepts. Central to the authors' approach is that development can best be understood by understanding how genes control cell behaviour. They have assumed that students have some basic familiarity with cell biology and genetics, but all key concepts, like the control of gene activity, are explained in the text. 'We have resisted the temptation to cover every aspect of development and have, instead, focused on those systems that best illuminate common principles. Indeed a theme that runs throughout the book is that universal principles govern the process of development' (Lewis Wolpert, Introduction) The focus of the text is on vertebrates and Drosophila, but not to the exclusion of other systems, such as the nematode and the sea urchin, where they best illustrate a concept. An important feature of the book is the inclusion of the development of plants, which is usually neglected in other textbooks, but has some unique and important features. Principles are presented as clearly as possible and numerous summaries are provided, both in words and in pictures. The illustrations in the book are a special feature, and have been carefully designed and chosen to illustrate both experiments and mechanisms.

Jessell, Thomas M.

Oxford Univ. Pr.

How does a single cell develop into myriad different specialised cell types, control the organization of these different cells into tissues and organs, and ultimately form an unimaginably complex living organism such as a human? Furthermore, how is it possible for some adult animals, but not others, to regenerate fully functioning limbs? Principles of Development opens up the fascinating field of developmental biology to those wanting to understand the answers to questions such as these. Cutting edge science is explained clearly and succinctly and is richly illustrated with a variety of custom drawn figures, animations, and links to online movies that show development happening in real time. The emphasis throughout the text is always on the key principles of development the underlying processes shared by diverse groups of organisms. This focus on principles provides a framework on which a richer understanding of specific topics can be built. Moreover, extensive pedagogical support is provided, both in the book and online, making this text the complete package for those studying developmental biology. Online Resources For students: Test your understanding with multiple choice questions and answer guidance to long answer questions from the book Gain a three dimensional perspective of development by watching the movies of developing model organisms View the signalling pathway animations to see these complex processes broken down step by step Expand your knowledge and guide your studies with the suggested web activities Examine and interpret raw data obtained by Cheryll Tickle and members of her laboratory and presented in silico For registered adopters of the text: Download the figures from the book to use in lectures and hand outs Help your students delve into the research literature with the Journal Club Download the test bank or import it into your VLE PowerPoint of In silico practicals to use in class

Led by Lewis Wolpert, an influential developmental biologist, this distinguished team of authors presents a new and revised edition of the best-selling and popular textbook Principles of Development. Central to their approach is an emphasis on principles and key concepts as well as the idea that understanding how genes control cell behavior is the key to comprehending development. The authors assume that students are familiar with the basics of cell biology and genetics but also provide thorough explanations of all key concepts in the text, such as the control of gene activity. The book focuses on those systems-such as vertebrates and Drosophila-that best illuminate the common principles of development, and also discusses other systems like the nematode and sea urchin. A unique feature of the book is its coverage of plant development, which is usually neglected in other textbooks but has significant relevance to the field of developmental biology. Full of spectacular illustrations and diagrams, Principles of Development, Second Edition, provides the excellent content and quality design of its predecessor, and also incorporates valuable new material.

Smith, Jim

Completely updated and revised in a new edition, Principles of Development presents major principles and concepts in the field for an undergraduate audience. Emphasizing gene control as the key to understanding development, the third edition is written in accessible prose, utilizing an impressive art program - 650 full color figures - as well as summaries and diagrams throughout the text to illuminate conceptually challenging material. In addition, the third edition presents carefully selected articles for further reading that expound on principles covered in the text.

Jessell, Tom

Robertson, Elizabeth

Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clearly a significant public health problem. As our knowledge of this illness has expanded in recent years, it has become clear that depression can no longer be viewed as a simple disorder of the brain. It has to be seen as a series of behavioural and biological changes that span mind, brain, genes, and body--indeed, affecting both psychological and physical health. This book brings together world leaders in research on depression to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psyschological, genetic, and evolutionary models with a particular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore, linking depression to physical health. Opening with a powerful, personal account of depression that conveys something of the all-consuming, debilitating nature of this illness, the book then presents cutting-edge research from those at the frontier of work in this area. The book is valuable for all those in the brain sciences seeking a state-of-the-art review of this global problem.

Understanding depression: A translational approach

Health, Fitness & Dieting

Nutt, David

Nesse, Randolph M.

Mental Health

See the best price to sell, buy, or rent books by Wolpert, Lewis. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Wolpert, Lewis

See the best price to sell, buy, or rent books by Wolpert, Lewis. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Principles of Development

A Passion for Science

The Triumph of the Embryo

The Triumph of the Embryo

Principles of Development

Principles of Development

Principles of Development

Principles of Development

Principles of Development

Understanding depression: A translational approach