<p>Iron is essential to most aerobic life-forms, facilitating transfer of both electrons and oxygen. It forms the active centre of many oxidases and oxygenases, and several anti-oxidants. <br>The authors present a chemical and biomedical perspective of how reactions of iron complexes and free radicals may contribute to human health and disease, especially in reactions of oxygen and hydrogen peroxide. Iron is discussed in terms of valence, high- and low- spin complexes, ligands - notably haem, oxygen, and nitric oxide-, its role in oxygen activation, and its transport, storage, and utilization, especially in humans. The link between iron and free radicals, especially via Fenton chemistry, and the central role of these reactions is discussed. <br>Free Radicals and Iron: Chemistry, Biology and Medicine is an accessible and comprehensive text describing a variety of reactions of iron in biological free-radical reactions. It presents both chemical and biochemical perspective, and should appeal to scientists and medical workers from many disciplines.</p>

Free Radicals and Iron: Chemistry, Biology, and Medicine

Science & Math

Symons, M.C.R.

Gutteridge, J. M. C.

Biological Sciences

Oxford University Press

Techniques in Free Radical Research (Volume 22) (Laboratory Techniques in Biochemistry and Molecular Biology, Volume 22)

Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.

Diplock, A.T.

Rice-Evans, C.A.

Elsevier Science

Chemical and biochemical aspects of electron-spin resonance spectroscopy

J. Wiley

Annual Reports on the Progress of Chemistry, Volume 83, 1986: Section C - Physical Chemistry (Annual Reports on the Progress of Chemistry Series)

Chemistry

Royal Society of Chemistry, [

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