Miracle Cure: The Creation of Antibiotics and the Birth of Modern Medicine

The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma. As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.

Science & Math

Rosen, William

History & Philosophy

Penguin??Books

From the acclaimed author of Miracle Cure and The Third Horseman, the epic story of the collision between one of nature's smallest organisms and history's mightiest empire During the golden age of the Roman Empire, Emperor Justinian reigned over a territory that stretched from Italy to North Africa. It was the zenith of his achievements and the last of them. In 542 AD, the bubonic plague struck. In weeks, the glorious classical world of Justinian had been plunged into the medieval and modern Europe was born. At its height, five thousand people died every day in Constantinople. Cities were completely depopulated. It was the first pandemic the world had ever known and it left its indelible mark: when the plague finally ended, more than 25 million people were dead. Weaving together history, microbiology, ecology, jurisprudence, theology, and epidemiology, Justinian's Flea is a unique and sweeping account of the little known event that changed the course of a continent.

Justinian's Flea: The First Great Plague and the End of the Roman Empire

Arts & Photography

History & Criticism

The incredible true story of how a cycle of rain, cold, disease, and warfare created the worst famine in European history—years before the Black Death, from the author of Justinian's Flea and the forthcoming Miracle Cure In May 1315, it started to rain. For the seven disastrous years that followed, Europeans would be visited by a series of curses unseen since the third book of Exodus: floods, ice, failures of crops and cattle, and epidemics not just of disease, but of pike, sword, and spear. All told, six million lives—one-eighth of Europe’s total population—would be lost. With a category-defying knowledge of science and history, William Rosen tells the stunning story of the oft-overlooked Great Famine with wit and drama and demonstrates what it all means for today’s discussions of climate change.

The Third Horseman: A Story of Weather, War, and the Famine History Forgot

History

Europe

The epic story of the collision between one of nature?s smallest organisms and history?s mightiest empire During the golden age of the Roman Empire, Emperor Justinian reigned over a territory that stretched from Italy to North Africa. It was the zenith of his achievements and the last of them. In 542 AD, the bubonic plague struck. In weeks, the glorious classical world of Justinian had been plunged into the medieval and modern Europe was born. At its height, five thousand people died every day in Constantinople. Cities were completely depopulated. It was the first pandemic the world had ever known and it left its indelible mark: when the plague finally ended, more than 25 million people were dead. Weaving together history, microbiology, ecology, jurisprudence, theology, and epidemiology, Justinian?s Flea is a unique and sweeping account of the little known event that changed the course of a continent.

Justinian's Flea: Plague, Empire and the Birth of Europe

World

VIKING

The Most Powerful Idea in the World:; A Story of Steam, Industry, & Invention [HC,2010]

Historical Study & Educational Resources

Jonathan Cape Ltd.

Hardly a week passes without some high-profile court case that features intellectual property at its center. But how did the belief that one could own an idea come about? And how did that belief change the way humankind lives and works? William Rosen, author of Justinian's Flea, seeks to answer these questions and more with The Most Powerful Idea in the World. A lively and passionate study of the engineering and scientific breakthroughs that led to the steam engine, this book argues that the very notion of intellectual property drove not only the invention of the steam engine but also the entire Industrial Revolution: history’s first sustained era of economic improvement. To do so, Rosen conjures up an eccentric cast of characters, including the legal philosophers who enabled most the inventive society in millennia, and the scientists and inventors—Thomas Newcomen, Robert Boyle, and James Watt—who helped to create and perfect the steam engine over the centuries. With wit and wide-ranging curiosity, Rosen explores the power of creativity, capital, and collaboration in the brilliant engineering of the steam engine and how this power source, which fueled factories, ships, and railroads, changed human history. Deeply informative and never dull, Rosen's account of one of the most important inventions made by humans is a rollicking ride through history, with careful scholarship and fast-paced prose in equal measure.

The Most Powerful Idea in the World: A Story of Steam, Industry, and Invention

Business & Money

Economics

University of Chicago Press

How a seven-year cycle of rain, cold, disease, and warfare created the worst famine in European history In May 1315, it started to rain. It didn’t stop anywhere in north Europe until August. Next came the four coldest winters in a millennium. Two separate animal epidemics killed nearly 80 percent of northern Europe’s livestock. Wars between Scotland and England, France and Flanders, and two rival claimants to the Holy Roman Empire destroyed all remaining farmland. After seven years, the combination of lost harvests, warfare, and pestilence would claim six million lives—one eighth of Europe’s total population. William Rosen draws on a wide array of disciplines, from military history to feudal law to agricultural economics and climatology, to trace the succession of traumas that caused the Great Famine. With dramatic appearances by Scotland’s William Wallace, and the luckless Edward II and his treacherous Queen Isabella, history’s best documented episode of catastrophic climate change comes alive, with powerful implications for future calamities.

The Third Horseman: Climate Change and the Great Famine of the 14th Century

The Emperor Justinian reunified Romes fractured empire by defeating the Goths and Vandals who had separated Italy, Spain, and North Africa from imperial rule. In his capital at Constantinople he built the world's most beautiful building, married its most powerful empress, and wrote its most enduring legal code, seemingly restoring Rome's fortunes for the next five hundred years. Then, in the summer of 542, he encountered a flea. The ensuing outbreak of bubonic plague killed five thousand people a day in Constantinople and nearly killed Justinian himself. 
 In Justinian's Flea , William Rosen tells the story of history's first pandemic plague seven centuries before the Black Death that killed tens of millions, devastated the empires of Persia and Rome, left a path of victims from Ireland to Iraq, and opened the way for the armies of Islam. Weaving together evolutionary microbiology, economics, military strategy, ecology, and ancient and modern medicine, Rosen offers a sweeping narrative of one of the great hinge moments in history, one that will appeal to readers of John Kelly's The Great Mortality , John Barry's The Great Influenza , and Jared Diamond's Collapse .

Justinian's Flea: Plague, Empire, and the Birth of Europe

Ancient Civilizations

Brécourt Academic

Pimlico

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Books by Rosen, William