<p>This book will present the current concept of autoimmune myasthenia gravis (MG) pathogenesis and strategy for specific therapy or cure for MG. MG is a classical autoimmune disease of the nervous system for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors and complement destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue and weakness. Target antigens have been characterized for only a very few other autoimmune diseases. Therefore, MG serves as a prototype for other autoimmune diseases, especially antibody-and/or complement-mediated autoimmune diseases (e.g., Graves disease, SLE, hemolytic anemia, pemphigus, etc.)In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model of experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR) and the MUSK protein. Preclinical and clinical trials have been performed utilizing the information gained in basic research. These advances are leading to the development of specific methods of immune intervention for MG.</p>

Myasthenia Gravis: Disease Mechanisms and Immune Intervention

Premkumar Christadoss

Linus Publications

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Books by Premkumar Christadoss

See the best price to sell, buy, or rent books by Premkumar Christadoss. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Myasthenia Gravis: Disease Mechanisms and Immune Intervention