The only book available in the area of forward-time population genetics simulations―applicable to both biomedical and evolutionary studies 
The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies. Forward-Time Population Genetics Simulations presents both new and commonly used methods, and introduces simuPOP, a powerful and flexible new program that can be used to simulate arbitrary evolutionary processes with unique features like customized chromosome types, arbitrary nonrandom mating schemes, virtual subpopulations, information fields, and Python operators. The book begins with an overview of important concepts and models, then goes on to show how simuPOP can simulate a number of standard population genetics models―with the goal of demonstrating the impact of genetic factors such as mutation, selection, and recombination on standard Wright-Fisher models. The rest of the book is devoted to applications of forward-time simulations in various research topics. Forward-Time Population Genetics Simulations includes: <ul>
<li> An overview of currently available forward-time simulation methods, their advantages, and shortcomings </li> <li> An overview and evaluation of currently available software </li> <li> A simuPOP tutorial </li> <li> Applications in population genetics </li> <li> Applications in genetic epidemiology, statistical genetics, and mapping complex human diseases </li> </ul>
The only book of its kind in the field today, Forward-Time Population Genetics Simulations will appeal to researchers and students of population and statistical genetics.

Forward-Time Population Genetics Simulations: Methods, Implementation, and Applications

Computers & Technology

Kimmel, Marek

Peng, Bo

Amos, Christopher I.

Computer Science

Wiley/Blackwell

Acquired Immune Deficiency Syndrome (AIDS) has been recognized since 1981; HIV (Human Immunodeficiency Virus) was identified in 1983; worldwide, millions of people have been infected and killed by it, yet AIDS is still considered a new disease. The medical world is still struggling to design satisfactory treatments for HIV and AIDS-related opportunistic diseases. In contrast to Western medicine, which focuses its research on the discovery of a single cure, Chinese medicine approaches the treatment of HIV & AIDS as it approaches all diseases, on the basis of syndrome differentiation tailored to the individual patient. Clinical research of the treatment of HIV and AIDS based on syndrome differentiation has encouraging prospects. At the heart of differential diagnosis lies the system of observation of patient signs and symptoms, and one the four main observation systems is the science of tongue diagnosis. Tongue diagnosis has a long and important history. Chinese medicine considers the tongue the external reflection, or mirror, of the zang and fu organs, which objectively reveals the real condition of patients. It plays a significant part in the evaluation of all disease conditions, choosing treatment direction and prognosis. Atlas of Tongue Diagnosis for AIDS Patients is a big step forward for clinicians everywhere, as it presents a clear introduction to the use of tongue diagnostic methods in the treatment of patients with HIV and AIDS based on correct syndrome. In two years of research, the tongues of 1,284 patients with AIDS and HIV were photographed -- of which 718 of these have been compiled into this volume. This book not only thoroughly presents the typical sorts of tongue manifestations in patients with AIDS and HIV, but many variations, and examples of patients with opportunistic diseases. The photographs in this book were taken with high-resolution digital cameras by professional photographers in natural lighting, and have been categorized after colorimetric analysis by experts. By presenting detailed pictures accompanied by accurate information in succinct language about each patients conditions, this book is immediately accessible in a practical sense. Readers of Atlas of Tongue Diagnosis for AIDS Patients will find that this presentation of both typical and uncommon tongue manifestations, will better aid them to cope with complicated situations with a flexible approach.

Atlas of Tongue Diagnosis for AIDS Patients

Health, Fitness & Dieting

Xie Shi-ping

Alternative Medicine

People's Medical Publishing House

G101平法钢筋计算精讲(第三版)

中国电力出版社

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