In this new book, Jack Li and Gordon Gribble have compiled an impressi ve array of richly referenced examples of the use of palladium in hete rocyclic chemistry. The book is organized by class of heterocycle (py rroles, indoles, pyridines, etc.) and each chapter contains the synthe ses of heterocyclic precursors as well as details of uses of palladium to both synthesize and functionalize these heterocyclic systems. Thi's book will appeal to anybody involved in heterocyclic chemistry, and will provide an easy entry into the field for those unfamiliar with th e area.

Palladium in Heterocyclic Chemistry: A Guide for the Synthetic Chemist (Volume 20) (Tetrahedron Organic Chemistry, Volume 20)

Science & Math

Li, Jie Jack

Gribble, Gordon

Chemistry

Pergamon

Palladium in Heterocyclic Chemistry, Volume 20: A Guide for the Synthetic Chemist (Tetrahedron Organic Chemistry)

Gribble, Gordon W.

Modern Organic Synthesis in the Laboratory

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

Limberakis, Chris

Pflum, Derek A.

Oxford University Press

The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.

Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use

History & Philosophy

Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.

Triumph of the Heart: The Story of Statins

It's time to examine the human history of viruses, vaccines, and antiviral drugs...\nPublic response to the COVID-19 pandemic has demonstrated that misinformation about viruses is widespread. Vaccine skepticism is rampant, and many people have been quick to accept bogus claims unsupported by science. In his latest book, Jie Jack Li sets the record straight by revealing the science and history behind antiviral drugs.\nConquest of Invisible Enemies: A Human History of Antiviral Drugs guides readers through the history of viruses, vaccinations, and treatments. Readers learn about the discovery of viruses and diseases, such as HIV/AIDS, hepatitis, influenza, and SARS-CoV-2 (COVID-19). The first chapter takes an expansive look at how viruses have shaped human history. Subsequent chapters narrow in on specific viruses, diseases, and drug treatments. For example, chapter four, on influenza, looks at the 1918 Spanish flu pandemic, the history of vaccination efforts, and influenza drugs and vaccines today. Chapter five, on coronaviruses, considers drug treatments for SARS, MERS, and SARS-CoV-2. It also discusses the development of COVID-19 vaccines and drugs.\nConquest of Invisible Enemies: A Human History of Antiviral Drugs focuses on the human drama behind drug discovery. Written in an engaging and accessible style, Li's timely book dispels common misconceptions about viruses and treatments and places the COVID-19 pandemic in historical context.

Conquest of Invisible Enemies: A Human History of Antiviral Drugs

Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.

Top Drugs: Their History, Pharmacology, and Syntheses

For the world's largest prescription drug manufacturers, the last few years have been a harrowing time. Recently, Pfizer's Lipitor, GlaxoSmithKline's Advair, AstraZeneca's Seroquel, and Sanofi-Aventis and Bristol-Myers Squibb's Plavix all came off patent in the crucial U.S. market. This so-called "patent cliff" meant hundreds of billions of dollars in lost revenue and has pharmaceutical developers scrambling to create new drugs and litigating to extend current patent protections. Having spent most of his career in drug discovery in "big pharma," Dr. Li now delivers an insider's account of how the drug industry ascended to its plateau and explores the nature of the turmoil it faces in the coming years. He begins with a survey of the landscape before "blockbuster drugs," and proceeds to describe how those drugs were discovered and subsequently became integral to the business models of large pharmaceutical companies. For example, in early 1980s, Tagamet, the first "blockbuster drug," transformed a minor Philadelphia-based drug maker named SmithKline &amp; French into the world's ninth-largest pharmaceutical company in terms of sales. The project that delivered Tagamet was nearly terminated several times because research efforts begun in 1964 produced no apparent results within the first eleven years. Similar stories accompany the discovery and development of now-ubiquitous prescription drugs, among them Claritin, Prilosec, Nexium, Plavix, and Ambien. These stories, and the facets of the pharmaceutical industry that they reveal, can teach us valuable lessons and reveal many crucial aspects about the future landscape of drug discovery. As always, Dr. Li writes in a readable style and intersperses fascinating stories of scientific discovery with engaging human drama.

Blockbuster Drugs: The Rise and Decline of the Pharmaceutical Industry

Business & Money

Industries

"A valuable addition to the literature by any measure and surely will prove its merit in years to come. The new knowledge that arises with its help will be impressive and of great benefit to humankind." ―From the Foreword by E. J. Corey, Nobel Prize Laureate 
An invaluable guide to name reactions and reagents for homologations Name Reactions for Homologations, Part I of Wiley's Comprehensive Name Reactions series comprises a comprehensive treatise on name reactions for homologations. With contributions from world-recognized authorities in the field, this reference offers an up-to-date, concise compilation of the most commonly used and widely known name reactions and reagents. Part I discusses Organometallics, Carbon-chain Homologation, and Radical Chemistry. Arranged alphabetically by name reactions, the listing provides: <ul>
<li> Description of the reaction </li> <li> Historical perspective </li> <li> A mechanism for the reaction </li> <li> Variations and improvements on the reaction </li> <li> Synthetic utilities of the reaction </li> <li> Experimental details </li> <li> References to the current primary literature </li> </ul>
Armed with this invaluable resource, both students and professionals will have at their fingertips a comprehensive guide to important mechanisms and phenomena in homologation.

Name Reactions for Homologation, Part 1 (Comprehensive Name Reactions)

wiley

See the best price to sell, buy, or rent books by Li, Jie Jack. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Li, Jie Jack

See the best price to sell, buy, or rent books by Li, Jie Jack. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Palladium in Heterocyclic Chemistry: A Guide for the Synthetic Chemist (Volume 20) (Tetrahedron Organic Chemistry, Volume 20)

Palladium in Heterocyclic Chemistry, Volume 20: A Guide for the Synthetic Chemist (Tetrahedron Organic Chemistry)

Modern Organic Synthesis in the Laboratory

Modern Organic Synthesis in the Laboratory

Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use

Triumph of the Heart: The Story of Statins

Conquest of Invisible Enemies: A Human History of Antiviral Drugs

Top Drugs: Their History, Pharmacology, and Syntheses

Blockbuster Drugs: The Rise and Decline of the Pharmaceutical Industry

Name Reactions for Homologation, Part 1 (Comprehensive Name Reactions)