A case history approach to drug synthesis and discovery Discover the origins of some of today’s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval.  This is a great reference for students in medicinal chemistry, researchers in pharmaceuticals, and medical practitioners.

New Drug Discovery and Development

Science & Math

Lednicer, Daniel

Chemistry

Wiley-Interscience

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

The Organic Chemistry of Drug Synthesis, Volume 7

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &amp;D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Strategies for Organic Drug Synthesis and Design

Steroid Chemistry at a Glance

The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry". 
Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include: <ul>
<li>history, isolation and structure determination of steroids</li> <li>steroid nomenclature and stereochemistry</li> <li>natural sources of steroids</li> <li>synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes</li> <li>steroids with a spirolactone at position 17</li> <li>steroids with hetrocyclic ring A</li> <li>compounds derived from cholesterol</li> </ul>
Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.

wiley

The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry". Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include:  history, isolation and structure determination of steroids steroid nomenclature and stereochemistry natural sources of steroids synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes steroids with a spirolactone at position 17 steroids with hetrocyclic ring A compounds derived from cholesterol  Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

The Organic Chemistry of Drug Synthesis, Volume 2 (Organic Chemistry Series of Drug Synthesis)

Mitscher, Lester A.

The Organic Chemistry of Drug Synthesis, Volume 3 (Organic Chemistry Series of Drug Synthesis)

The classic reference on the synthesis of medicinal agents --now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6.Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

The Organic Chemistry of Drug Synthesis

All of the breadth and depth of organic drug synthesis-in one resource This work offers a clear examination of the synthetic routes followed to prepare a range of compounds with assigned generic names. With drugs selected for the illustrative value of the chemistry used for synthesis, the book illustrates a great variety of organic transformations and structural classes of compounds. Ideal for anyone learning or working in organic, medicinal, or pharmaceutical chemistry today, Strategies for Organic Drug Synthesis and Design includes: * Coverage of carbocyclic and heterocyclic compounds-steroids, opioid analgesics, beta lactam antibiotics, and more * Hundreds of reaction flow charts detailing routes used to prepare over 600 compounds * Biological rationales for drug classes and actions of individual agents * Capsule presentations of basic principles of drug action * An extensive chemical reaction index with over 3,000 entries.

The Organic Chemistry of Drug Synthesis, Volume 6 covers the literature on the synthesis of medicinal agents from 1994 to 1998. This well-received series meets the needs of practitioners in the field who seek a quick overview of the synthetic routes that have been used to access specific classes of therapeutic agents. While most books on medicinal chemistry are organized on the basis of therapeutic or biochemical classes, materials in this series are arranged and discussed in terms of chemical structure. Thus, the preparation and detailed organic chemistry of the classes are presented in a unified way. Only drugs that have been granted a U.S. Adopted Name are included in this series. Synthetic organic, pharmaceutical, medicinal, and heterocyclic chemists will find this series an invaluable resource for their research in the synthetic chemistry of drug development.

The Organic Chemistry of Drug Synthesis, Vol. 6

See the best price to sell, buy, or rent books by Lednicer, Daniel. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Lednicer, Daniel

See the best price to sell, buy, or rent books by Lednicer, Daniel. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

New Drug Discovery and Development

The Organic Chemistry of Drug Synthesis, Volume 7

Strategies for Organic Drug Synthesis and Design

Steroid Chemistry at a Glance

Steroid Chemistry at a Glance

The Organic Chemistry of Drug Synthesis, Volume 2 (Organic Chemistry Series of Drug Synthesis)

The Organic Chemistry of Drug Synthesis, Volume 3 (Organic Chemistry Series of Drug Synthesis)

The Organic Chemistry of Drug Synthesis

Strategies for Organic Drug Synthesis and Design

The Organic Chemistry of Drug Synthesis, Vol. 6