The accurate diagnosis of haematologic malignancies is a complex and challenging task. It routinely involves morphologic, molecular, cytogenetic and flow cytometric expertise. To determine what treatment protocol will be followed, it is vital to integrate, interpret and report these results accurately. Flow cytometry is key in this diagnostic pathway. This book guides the reader as to how flow cytometry results should be interpreted and applied to optimize patient care. At the core of this text is an appreciation of clinical, morphological and immunophenotypic correlation and the importance of constant liaison and discussion between the medical and scientific teams. The authors present a logical and practical approach to the diagnosis of blood disorders (both neoplastic and reactive) and evaluate the diagnostic applications of flow cytometry. Practical Flow Cytometry in Haematology Diagnosis provides: • A clinical reference source on all aspects of flow cytometry, covering both malignant and benign conditions • Carefully chosen real-life cases in each chapter, complemented by high quality morphological images • Help in making a diagnosis, together with an understanding of the limitations of the technique and the potential pitfalls All those who instigate, perform, interpret or act upon flow cytometry patient material will find this book an invaluable guide.

Practical Flow Cytometry in Haematology Diagnosis

Medical Books

Leach, Mike

Drummond, Mark

Doig, Allyson

Medicine

Wiley/Blackwell

Improve the performance of relational databases with indexes designed for today's hardware Over the last few years, hardware and software have advanced beyond all recognition, so it's hardly surprising that relational database performance now receives much less attention. Unfortunately, the reality is that the improved hardware hasn't kept pace with the ever-increasing quantity of data processed today. Although disk packing densities have increased enormously, making storage costs extremely low and sequential read very fast, random reads are still painfully slow. Many of the old design recommendations are therefore no longer valid-the optimal point of indexing has come a long way. Consequently many of the old problems haven't actually gone away-they have simply changed their appearance. This book provides an easy but effective approach to the design of indexes and tables. Using lots of examples and case studies, the authors describe how the DB2, Oracle, and SQL Server optimizers determine how to access data, and how CPU and response times for the resulting access paths can be quickly estimated. This enables comparisons to be made of the various designs, and helps you choose available choices for the most appropriate design. This book is intended for anyone who wants to understand the issues of SQL performance or how to design tables and indexes effectively. With this title, readers with many years of experience of relational systems will be able to better grasp the implications that have been brought into play by the introduction of new hardware.

Relational Database Index Design and the Optimizers

Computers & Technology

Lahdenmaki, Tapio

Networking & Cloud Computing

Wiley-Interscience

SWING YOUR SWORD is the first ever book by one of the most fascinating and successful coaches in sports today. A maverick who took an unlikely path to coaching through law school, Mike Leach talks about his unorthodox approach to coaching and the choices that have brought him success throughout his career. A lover of the game who started creating formations and drawing his own plays as a kid, Leach took his Texas Tech Red Raiders to numerous bowl games, achieving the #2 slot in national rankings and being voted 2008 Coach of the Year before being unceremoniously fired at the end of the 2009 season. The scandalous nature of his dismissal created a media frenzy and began a personal battle between Leach and his accusers that remains unresolved.

Swing Your Sword: Leading the Charge in Football and Life

Sports & Outdoors

Biographies

Diversion Books

The analysis of blood, bone marrow and tissue fluid specimens requires a multi-faceted approach with the integration of scientific data from a number of disciplines. No single discipline can operate in isolation or errors will occur. Flow cytometry is in a privileged position in that it can provide rapid analysis of specimens and it is often the first definitive investigation to produce results and help formulate a working diagnosis. This companion text to Practical Flow Cytometry in Haematology Diagnosis contains 100 worked examples drawn from real clinical cases presenting to the authors’ institution. Cases are illustrated with peripheral blood and bone marrow cytology, tissue pathology and cytogenetic and molecular data, which are integrated to generate, where appropriate, a diagnosis based on the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The spectrum of clinical cases includes adult and paediatric patients, and both neoplastic and reactive disorders. The cases appear in no particular order to challenge the reader to make their own diagnosis. The reader will review May-Grünwald-Giemsa (MGG)-stained films of peripheral blood and bone marrow aspirates presented alongside flow cytometric data and haematoxylin and eosin (H&amp;E)-stained bone marrow and other tissue biopsy sections. Immunohistochemistry is used to further clarify the tissue lineage and cell differentiation. Cytogenetic studies using metaphase preparations are used to identify translocations and chromosome gains and losses whilst interphase fluorescence in situ hybridisation (FISH) studies and polymerase chain reaction (PCR) are used to identify gene fusions, gene rearrangements and deletions. Each case concludes with a discussion of the features that are important to making a diagnosis. The cases are also listed according to disease classification in the appendix so that the text can also be used as a reference. Practical Flow Cytometry in Haematology: 100 Worked Examples: <ul>
<li>Provides a practical, example-based resource for flow cytometry</li> <li>Demonstrates how flow cytometry results should be interpreted and applied to optimize patient care</li> <li>Includes both malignant and benign conditions</li> <li>Can be used in conjunction with Practical Flow Cytometry in Haematology Diagnosis, by the same author team (ISBN 9780470671207)</li> </ul>
Practical Flow Cytometry in Haematology: 100 Worked Examples is ideal for practicing haematologists and histopathologists with an interest in haematopathology, but particularly directed at trainee haematologists and scientists preparing for FRCPath and related examinations.

Practical Flow Cytometry in Haematology: 100 Worked Examples

Bain, Barbara J.

Jackson, Bob

McKay, Pam

Offers clear and concise instruction on running,&nbsp;reporting and interpreting immunophenotyping studies&nbsp; Written by two well-known&nbsp;haematology&nbsp;educators and experts on the topic,&nbsp;Immunophenotyping for&nbsp;Haematologists&nbsp;contains an introduction to running, reporting and interpreting immunophenotyping studies. The book&nbsp;offers a unique approach to the topic by putting the focus on clinical&nbsp;and laboratory&nbsp;haematologists&nbsp;who are not routinely involved in running and reporting on&nbsp;immunophenotyping&nbsp;studies.&nbsp; Immunophenotyping using flow cytometry has become the method of choice in identifying and sorting cells within complex populations, for example, the analysis of immune&nbsp;or neoplastic&nbsp;cells in a blood sample.&nbsp;The text reviews the purpose and principles of&nbsp;immunophenotyping&nbsp;and includes an introduction and explanation of the principles and the role of&nbsp;immunophenotyping. The authors examine immunophenotypic characteristics of the disease groups commonly encountered and&nbsp;identify&nbsp;the features that differentiate malignant cells from normal cells. To enhance understanding, the book contains&nbsp;multiple choice and extended matching questions which integrates immunophenotyping with clinicopathological features and the results of other investigations to mimic everyday practice.&nbsp; This important book:&nbsp; <ul style="margin-bottom: 0in; font-size: medium; margin-top: 0in; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cursor: text; overflow: visible;"> <li style="margin: 0in 0in 0.0001pt 0.25in; font-size: 11pt; font-family: Calibri, sans-serif; vertical-align: baseline; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cursor: text; overflow: visible;">Provides a concise introduction to running, reporting and interpreting immunophenotyping studies&nbsp;</li> <li style="margin: 0in 0in 0.0001pt 0.25in; font-size: 11pt; font-family: Calibri, sans-serif; vertical-align: baseline; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cursor: text; overflow: visible;">Contains a list of all&nbsp;the&nbsp;antibody specificities currently&nbsp;widely&nbsp;used in diagnosis and disease monitoring&nbsp;</li> <li style="margin: 0in 0in 0.0001pt 0.25in; font-size: 11pt; font-family: Calibri, sans-serif; vertical-align: baseline; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cursor: text; overflow: visible;">Presents an ideal reference for use in&nbsp;laboratories, including immunophenotyping laboratories&nbsp;&nbsp;</li> <li style="margin: 0in 0in 0.0001pt 0.25in; font-size: 11pt; font-family: Calibri, sans-serif; vertical-align: baseline; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cursor: text; overflow: visible;">Aids in the interpretation by covering&nbsp;immunophenotypic&nbsp;characteristics of commonly encountered disease groups&nbsp;</li> <li style="margin: 0in 0in 0.0001pt 0.25in; font-size: 11pt; font-family: Calibri, sans-serif; vertical-align: baseline; user-select: text; -webkit-user-drag: none; -webkit-tap-highlight-color: transparent; cursor: text; overflow: visible;">Identifies the features that differentiate malignant cells from their normal counterparts&nbsp;</li> </ul> Written for&nbsp;haematologists&nbsp;working in both laboratory and clinical&nbsp;haematology,&nbsp;Immunophenotyping for&nbsp;Haematologists&nbsp;is a much-needed reference for understanding and interpreting&nbsp;immunophenotyping&nbsp;studies.&nbsp;

Immunophenotyping for Haematologists: Principles and Practice

Haematology Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue ­fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct&nbsp;descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

Haematology: From the Image to the Diagnosis

Leukaemia Diagnosis

Lords of Circumstance is a story of tragedy and redemption that spans two generations, extraordinarily connected by the whims of fate. It examines the shrinking proximity of unspeakable disaster that we all suppress for the sake of sanity. Between the Korean War and the killing fields of Vietnam, the Cold War Era becomes a proving ground for increasingly complex, engineered viruses. While the world focuses on nuclear threats, our enemies are rapidly developing alternative methods of achieving world domination. One man has peeked inside Pandora's Box and discovered a soulless aggressor. On the opposite side of the world, the lives of best friends Matt Garrett and Bill Hunter follow widely divergent paths after high school, only to be reunited as adults in pursuit of a common goal. With the formation of the elite, U.S. government "LOC" team, the characters are swept up in a global effort to locate the ultimate biological weapon, developed by a Russian scientist whose research was decades ahead of its time. Deadly secrets lead to incredible revelations, leaving us to question the tenuous fabric of our daily lives.

Lords of Circumstance

Literature & Fiction

CreateSpace Independent Publishing Platform

Reminiscent of The 48 Laws of Power, legendary football coach Mike Leach’s inspiring history of Apache war leader Geronimo demonstrates the timeless lessons we can learn from his life—featuring a foreword from the bestselling author of Empire of the Summer Moon. Says New York Times bestselling author Brian Kilmeade, "Mike Leach put together a compelling book and humanized a man many thought never existed. A great read." Playing cowboys and Indians as a boy, legendary college football coach Mike Leach always chose to be the Indian—the underdog whose success turned on being a tough, resourceful, ingenious fighter. And the greatest Indian military leader of all was Geronimo, the Apache warrior whose name is so symbolic of courage that World War II paratroopers shouted it as they leaped from airplanes into battle. Told in the style of The 48 Laws of Power, Leach’s compelling and inspiring book examines Geronimo’s leadership approach and the timeless strategies, decisions, and personal qualities that made him a success. Raised in an unforgiving landscape, Geronimo and his band faced enemies better armed, better equipped, and more numerous than they were. But somehow they won victories against all odds, beguiling the United States and Mexican governments and earning the respect and awe of those generals committed to hunting him down. While some believed that Geronimo had supernatural powers, much of his genius can be ascribed to old-fashioned values such as relentless training and preparation, leveraging resources, finding ways to turn defeats into victories, and being faster and more nimble than his enemy. The tactics of Geronimo would be studied and copied by the U.S. military for generations. Drawing on his fascination and love for American Indian lore, Mike Leach explains how the tribe’s organizational structure helped Geronimo be successful. He chronicles specific battles and shows how Geronimo got the most out of his warriors and outthought his enemies. Leach also captures the mysterious nature of leadership itself. Pain, pride, humility, family—many things shaped Geronimo’s life. In this remarkable book, Mike Leach illustrates how we too can use the forces and circumstances of our own lives to build true leadership today.

Geronimo: Leadership Strategies of an American Warrior

Biographies & Memoirs

Levy, Buddy

Historical

GALLERY BOOKS

“In the hands of Mike Leach and Buddy Levy, the story of this brilliant Apache leader comes into sharp focus, both in their narrative of his life and in spirited commentaries on its meaning” (S.C. Gwynne, author of Pulitzer Prize finalist Empire of the Summer Moon). Playing cowboys and Indians as a boy, legendary college football coach Mike Leach always chose to be the Indian—the underdog whose success turned on being a tough, resourceful, ingenious fighter. And the greatest Indian military leader of all was Geronimo, the Apache warrior whose name is so symbolic of courage that World War II paratroopers shouted it as they leaped from airplanes into battle. Told in the style of Robert Greene’s The 48 Laws of Power, Leach’s compelling and inspiring book examines Geronimo’s leadership approach and the timeless strategies, decisions, and personal qualities that made him a success. Raised in an unforgiving landscape, Geronimo and his band faced enemies better armed, better equipped, and more numerous than they were. But somehow they won victories against all odds, beguiling the United States and Mexican governments and earning the respect and awe of those generals committed to hunting him down. While some believed that Geronimo had supernatural powers, much of his genius can be ascribed to old-fashioned values such as relentless training and preparation, leveraging resources, finding ways to turn defeats into victories, and being faster and more nimble than his enemy. The tactics of Geronimo would be studied and copied by the US military for generations. Pain, pride, humility, family—many things shaped Geronimo’s life. In this “compelling book that humanizes a man many misunderstood” (New York Times bestselling author Brian Kilmeade), Mike Leach illustrates how we too can use the forces and circumstances of our own lives to build true leadership today.

See the best price to sell, buy, or rent books by Leach, Mike. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Books by Leach, Mike

See the best price to sell, buy, or rent books by Leach, Mike. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Practical Flow Cytometry in Haematology Diagnosis

Relational Database Index Design and the Optimizers

Swing Your Sword: Leading the Charge in Football and Life

Practical Flow Cytometry in Haematology: 100 Worked Examples

Immunophenotyping for Haematologists: Principles and Practice

Haematology: From the Image to the Diagnosis

Leukaemia Diagnosis

Lords of Circumstance

Geronimo: Leadership Strategies of an American Warrior

Geronimo: Leadership Strategies of an American Warrior