Gene Regulation : A Eukaryotic Perspective

"Gene Regulation" provides a view of gene control systems from a eukaryotic standpoint, and tries to redress the bias towards prokaryotic control models. The text explores a variety of regulational strategies and defines their functional significance to the organism as a whole. The opening chapters examine the possible processes and mechanisms by which genes could be controlled at different levels, and establish that the key control structures lie at the level of gene transciption. Further chapters continue with an examination of the various steps in transcriptional regulation and explain how events at the molecular level finally have their impact on the biology of the organism via the expression of a diversity of proteins. The final section takes a look at the role of malregulation of gene expression in causing human diseases, particularly in relation to certain forms of cancer. This book should appeal to a wide range of intermediate and advanced students of molecular biology, biochemistry, genetics and clinicians working in these areas.

Science & Math

Latchman, David S.

Biological Sciences

Springer

"Gene Regulation" provides a view of gene control systems from a eukaryotic standpoint, and tries to redress the bias towards prokaryotic control models. The text explores a variety of regulational strategies and defines their functional significance to the organism as a whole. The opening chapters examine the possible processes and mechanisms by which genes could be controlled at different levels, and establish that the key control structures lie at the level of gene transcription. Further chapters continue with an examination of the various steps in transcriptional regulation and explain how events at the molecular level finally have their impact on the biology of the organism via the expression of a diversity of proteins. The final section takes a look at the role of malregulation of gene expression in causing human diseases, particularly in relation to certain forms of cancer. This book should appeal to a wide range of intermediate and advanced students of molecular biology, biochemistry, genetics and clinicians working in these areas.

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.

Eukaryotic Transcription Factors

Academic Press

Intended for final year undergraduate and postgraduate students in molecular biology and biochemistry, this book discusses in detail information currently available on transcription factors, emphasizing common motifs, themes and mechanisms. It summarizes the major families, describes the mechanics of activation and repression of eukaryotic genes by transcription factors, and explains the relationship between the structure and function of these factors. Furthermore, it highlights the importance of transcription factors during the development, differentiation and transformation of eukaryotic cells, and provides the principles behind the methods employed to study transcription factors in vivo and in vitro.

Academic Pr

The revised edition of this book provides an up-to-date overview of the role of transcription factors in gene regulation, focusing primarily on the role of individual specific factors in biological processes such as the steroid response, and cell-type determination. Transcription factors play a fundamental role in turning genes on and off in particular cell types, during embryonic development, or in response to specific skills and are of interest to scientists from a variety of disciplines. However, the bewildering array of these proteins and the different ways in which they act can prove daunting to scientists and newcomers to molecular genetics. This book aims to provide the reader with a clear understanding of this field. It should be useful reading for those who seriously wish to understand the impact of molecular biology on medicine, whatever their speciality.

Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act.  Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality.                                       * Major families of eukaryotic transcription factors described* Mechanisms of gene activation and repression analysed* Structure-function relationships indicated* Interaction between transcription factors and chromatin structure described* Roles in inducible and cell type-specific gene expression * Roles in development, differentiation and human diseases including cancer* Methods of study in vitro and in vivo

Eukaryotic Transcrption Fctrs 2e Ppr APL

Familiarity with the mechanisms of eukaryotic gene regulation is now essential for scientists and students in both clinical and basic disciplines. However, the vast array of transcription factors, which are central to such regulation, can prove daunting to students and newcomers to this fascinating field of molecular genetics. The Third Edition of Eukaryotic Transcription Factors provides the reader with a clear and concise understanding not only of transcription factors, but also of their vital role in the regulation of transcription in different cell types during development and in disease.Revised and completely up-to-date, the Third Edition of Eukaryotic Transcription Factors has been extensively rewritten to reflect the rapid advances in the field. These include the emerging roles of specific co-activator molecules such as CBP in the action of a number of different transcription factors emphasizing particularly their ability to modulate chromatin structure. New sections cover current methods for determining DNA binding specificity, regulation by protein degradation and processing, Pax family transcription factors, and novel anti-oncogenic transcription factors, as well as a discussion of transcription factors in human diseases. A special new color section illustrates the various aspects of transcription factor structure. Emphasising common motifs, themes and mechanisms this volume covers:* Major families of eukaryotic transcription factors* Mechanisms of gene activation and repression* Structure-function relationships* Their roles in inducible and cell type-specific gene expression, development, differentiation, and human diseases including cancer* Methods of study in vivo and in vitro

Eukaryotic Transcription Factors, Third Edition

Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors. This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality.

Gene Regulation provides a complete and concise picture of the  processes regulating gene expression in higher organisms and man. The  second edition of this well reviewed textbook has been extensively  updated to reflect the scientific progress made in this area over the  last four years.

Gene Regulation: A Eukaryotic Perspective

Chapman & Hall

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Books by Latchman, David S.

See the best price to sell, buy, or rent books by Latchman, David S.. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Gene Regulation : A Eukaryotic Perspective

Gene Regulation : A Eukaryotic Perspective

Eukaryotic Transcription Factors

Eukaryotic Transcription Factors

Eukaryotic Transcription Factors

Eukaryotic Transcrption Fctrs 2e Ppr APL

Eukaryotic Transcription Factors

Eukaryotic Transcription Factors, Third Edition

Eukaryotic Transcription Factors

Gene Regulation: A Eukaryotic Perspective