Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Science & Math

Lacy, Charles F.

Howie, Alexander J.

Goldman, Morton P.

Lance, Leonard L.

FRIEDMAN, HERMAN

Weisman

Katz, Lynda J.

Goldstein, Gerald

Beers, Sue R.

Young, David B.

Honeyman, Allen

Lajtha, Able

Bendinelli, Mauro

Newland, Robert

Biological Sciences

Springer

Quick Look Drug Book 2008

Medical Books

Armstrong, Lora L.

Goodman, Morton P.

Pharmacology

Lippincott, Williams, & Wilkins

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Quick Look Drug Book

Medicine

Quick Look Drug Book 2009 includes the most current information on thousands of commonly used drugs, plus a 32-page color insert showing the 200 most commonly prescribed medications. Medical transcriptionists and other healthcare professionals rely on this comprehensive resource for information on brand and generic drug names, pronunciations, look-alike/sound-alike issues, therapeutic categories, dosages, and dosage forms. Exclusive to Quick Look Drug Book is the Indication/Therapeutic Category Index that lists conditions/diseases alphabetically with the drugs used to treat them. Updates include new drugs introduced or approved by the FDA in 2008. Nine appendices are included. The CD-ROM version has search functions that allow super-fast reference. See CD-ROM listing for details on Quick Look Electronic Drug Reference 2009.

Quick Look Drug Book 2009

Health, Fitness & Dieting

Reference

...compiled specifically for the health care professional who needs quick access to concisely stated drug information ...covers 975 medications that have up to 24 key fields of data.

Drug Information Handbook, 1996-97 (DRUG INFORMATION HANDBOOK FOR THE ALLIED HEALTH PROFESSIONAL)

Ingrim, Naomi

Nursing

Lexi-Comp, Inc.

...a concise, easy-to-follow, and unified compendium covering 1029 medications with up to 28 key points of commonly requested information provided by each monograph... with a therapeutic category and key-word index.

Drug Information Handbook 1997-98 (LEXI-COMP'S CLINICAL REFERENCE LIBRARY)

Ingrim, Naomi B.

...specifically compiled for physicians, pharmacists and nurses, with up to 29 fields of information...a concise and comprehensive resource, in an easily accessible alphabetical and itemized format...with over 1,025 generic monographs.

Drug Information Handbook

Politics & Social Sciences

Social Sciences

Amer Assn for Clinical Chemistry

...updated to include information on new drugs as well as updated monographs and appendices...with Canadian and Mexican brand names, test interactions, nursing implications, dietary considerations, and outstanding cross-referencing.

Drug Information Handbook: Pocket, 1999-2000

This handbook is specifically compiled and designed for the healthcare professional requiring quick access to concisely stated comprehensive data concerning the clinical use of medications.

Nevada College of Pharmacy, Las Vegas. Annual reference is the pocket-sized edition of the text of the same title, listed in week 2004-12. Features more than 1,300 drug monographs with numerous fields of information for each. Softcover.

Drug Information Handbook: 2004-2005

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