Three-Dimensional Electron Microscopy of Macromolecular Assemblies is the first systematic introduction to single-particle methods of reconstruction. It covers correlation alignment, classification, 3D reconstruction, restoration, and interpretation of the resulting 3D images in macromolecular assemblies. It will be an indispensable resource for newcomers to the field and for all using or adopting these methods. Key Features * Presents methods that offer an alternative to crystallographic techniques for molecules that cannot be crystallized * Describes methods that have been instrumental in exploring the three-dimensional structure of * the nuclear pore complex * the calcium release channel; * the ribosome * chaperonins

Three-Dimensional Electron Microscopy of Macromolecular Assemblies

Science & Math

Frank, Joachim

Biological Sciences

Academic Press

Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State

Cryoelectron microscopy of biological molecules is among the hottest growth areas in biophysics and structural biology at present, and Frank is arguably the most distinguished practitioner of this art. CryoEM is likely over the next few years to take over much of the structural approaches currently requiring X-ray crystallography, because one can now get good and finely detailed images of single molecules down to as little as 200,000 MW, covering a substantial share of the molecules of greatest biomedical research interest. This book, the successor to an earlier work published in 1996 with Academic Press, is a natural companion work to our forthcoming book on electron crystallography by Robert Glaeser, with contributions by six others, including Frank. A growing number of workers will employ CryoEM for structural studies in their own research, and a large proportion of biomedical researchers will have a growing interest in understanding what the capabilities and limits of this approach are.

Oxford University Press

Why do some people achieve outstanding success while many who work hard do not accomplish much and settle for ordinary life after some fruitless attempts at success?This book contains the testimonies of a good number of people who are globally recognized as accomplished individuals. Their stories provide a clue to the answer to that question. They say even though success does not seem to have a formula, determined individuals can overcome difficult challenges and become outstanding achievers. Their stories and the principles of success the curator of the book gathered from over 400 distinguished achievers from around the world indicate that the route to success is full of seeming contradictions. Understanding those seeming contradictions generally provides the key to what you want. The lessons in this book will aid your understanding of the barriers standing between you and your goals and point you in the direction of life of significance. The individuals serving as your guides through their stories and advice have used the ideas they have presented in this book to achieve outstanding success. It has taken some of them over five decades of diligent work to arrive at their current prestigious positions. Your own journey does not have to take that long. You can pick up the principles that have taken them that long to learn while on a bus ride to work. That may be how much time it will take you to finish this book. Smart people learn from the mistakes and right steps of others. This book may be all you need to accomplish much more than you currently desire. The lessons in it have come from Nobel Prize Winners, Presidents of countries, religious leaders, youth activists, outstanding business men and women and innovators benefitting our world with their products and services. They come from America, Europe, Africa and other continents. Enrich your network. Buy copies for some of its members.

Inspiring Stories From Amazing People: From Presidents, Youth Activists, Nobel Prize Winners, YouTubers, Leading Academics, & Innovators of Diverse Ages, Professions, Countries and Continents

Self-Help

Levitt, Michael

Adelaja, Sunday

Csíkszentmihályi, Mihály

Thomasson, Amie

Hall, John

Ahtisaari, Martti

Myers,David

Ogudoro, Marvellous

Malkmus, George

Motivational

Independently published

1989er Schicksale: Wendegeschichten

May, Melissa

Gornik, Jutta

Kess, Inga

Schmidt, Dörte

Engelken, Christian

Opfinger, Heidemarie

Buggenhagen, Ramona Ina

Daschek, Bernd

Wübken, Andrea

Papenfuß, Josina

Schmalwieser, Susanne Sophie

Benefeld-Süß, Uta

Möller, Dorothea

Reifenstahl, Sabine

Rödig, Wolfgang

Voß, Joachim

Handge, Renate

Hoffmeister, Lena

Meister, Jo Kilian

Khachapuridse, Tengis

Kormann, Christa

Lange, Michael Johannes B.

net-Verlag

Novel Developments in Cryo‐EM of Biological Molecules: Resolution in Time and State Space

Jenny Stanford Publishing

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Books by Frank, Joachim