Based on the author's study of some 200 patients, and on a detailed review of the literature, this volume examines all aspects of Duchenne muscular dystrophy--the second most common genetic disorder affecting humans.  Topics include the history of the disease, clinical features, involvement of tissues other than muscle, laboratory investigations, differential diagnosis, biochemistry, pathogenesis, genetics, molecular pathology, prevention, genetic counselling, and surgical and medical management. The book is illustrated with numerous photographs and line drawings, and includes an extensive bibliography.

Duchenne Muscular Dystrophy (Oxford Monographs on Medical Genetics)

Emery, Alan E.H.

Medical Books

Oxford University Press

Based on the author's study of some 200 patients and a detailed review of the literature, this volume provides a comprehensive and clinical account of all aspects of Duchenne muscular dystrophy--the second most common genetic disorder affecting humans. During the last decade, biochemists and molecular biologists have made a huge effort to understand the basic molecular defect. In 1986, when this book was first in press, Professor Emery was able to predict with some confidence that the locus of the gene responsible would soon be identified. The publication of this revised paperback edition offers the opportunity to bring his account up-to-date with a discussion of the isolation of the gene and its unexpected size and complexity, followed by the characterization of the related protein dystrophin, a component of skeletal muscle.

This is the second edition of a highly acclaimed monograph. It is currently the only book which considers Duchenne Muscular Dystrophy (DMD) in detail and critically evaluates the extensive published literature. The author draws on his extensive clinical experience and scientific knowledge to provide an account of one of the most common inherited diseases. After a brief historical introduction, he describes the clinical features of the disease, emphasizing the involvement of tissues other than skeletal muscle. The biochemistry, genetics, and molecular pathology are discussed in the context of recent research findings, building a picture of the role of dystrophin in the pathogenesis of the disease. Prevention through neonatal screening, carrier detection, genetic counseling, and prenatal diagnosis is covered extensively, stressing the importance of DNA markers and gene probes. Finally, the book discusses the management of patients with the disease and the possibilities for treatment, which include surgical correction of deformities, new drug treatments, the prospects for myoblast transfer, and the possibilities for gene therapy.

History

Americas

Muscular Dystrophy: The Facts (The ^AFacts Series)

The muscular dystrophies are a group of genetic diseases that severely affect children and adults. Muscular Dystrophy: The Facts examines living with muscular dystrophy and coping with its physical and psychological effects. Written specifically for people with muscular dystrophy and their families, it will answer many of the questions that are often asked about how and why it occurs, and how it will affect the life of a recently diagnosed child. The different types of muscular dystrophy are described with the minimum of technical jargon. Questions relating to exercise, physiotherapy, surgery, and the emotional effects of the disease are answered, and advice is given on the problems of schooling and choice of career. At the end of the book Professor Emery also provides a useful list of international muscular dystrophy groups and associations.

Parenting & Relationships

The muscular dystrophies are a group of genetic diseases that severely affect children and adults. Ths book is about living with muscular dystrophy, and coping with its physical and psychological effects. Written specifically for people with muscular dystrophy and their families, it should answer many of the questions that are often asked about how and why it occurs, and how it will affect the life of a recently diagnosed child. The different types of muscular dystrophy are described with the minimum of technical jargon. Questions relating to exercise, physiotherapy, surgery and the emotional effects of the disease are answered, and advice is given on the problems of schooling and choice of career. At the end of the book, Professor Emery also provides a useful list of international muscular dystrophy groups and associations. Alan E.H. Emery is the author of "Duchenne Muscular Dystrophy" (2nd edition).

Health, Fitness & Dieting

Diseases & Physical Ailments

The muscular dystrophies are a group of genetic diseases that severely affect children and adults. For sufferers and their family, the illness presents enormous physical and psychological challenges. Written specifically for people with muscular dystrophy and their families, this book answers many of the questions asked about how and why muscular dystrophy occurs, and how it will affect the life of a recently diagnosed child. As well as presenting the reader with advice and an explanation of muscular dystrophy, the book also guides the reader towards further information on societies and support groups around the world, and reliable internet resources. It also contains a full glossary to aid the reader in their understanding of the disease. The different types of muscular dystrophy are described throughout with a minimum of technical jargon. Questions relating to exercise, physiotherapy, surgery, and the emotional effects of the diseases are answered, and advice is given on the problems of schooling and choice of career. Since publication of the first edition in 1994, the genes for almost all the different types of dystrophy have been identified, enabling prevention through genetic counselling, therefore relieving some of the worry for affected families. Drawn from his many years of experience treating patients, Professor Emery provides authoritative, yet compassionate advice for people living with this illness.

Muscular Dystrophy (The ^AFacts Series)

Duchenne Muscular Dystrophy is a disease that only affects males, with an incidence of around 1 in 3500 new-born baby boys. Its relentless progress is charterized by loss of the ability to walk by around the age of 10 or 11, leading to a wheelchair life, and dealth from cardiac and respiratory problems usually around the late teens or early twenties. Edward Meryon was the first person to give a full and detailed clinical description of what later research knows as Duchenne Muscular Dystrophy. His research identified many facets of the condition which we now take for granted, for example that it only affects males, that it is an inherited condition carried in female genes, that it is a disease of the muscle system, and its causes. Until recently, Meryon has not been given credit for his contribution to the subject. In this book, the history of Duchenne Muscular Dystrophy is traced in detail, and is interwoven with a commentary of Meryon's research which has led to our current understanding of the disease, will full refences and informative, historically relevant illustrations. This book concludes with a summary of the current position regarding diagnosis, prevention through counselling and prenatal diagnosis, and new encouraging approaches to treatment through molecular genetics.

The History of a Genetic Disease: Duchenne Muscular Dystrophy or Meryon's Disease (Oxford Medical Histories)

Science & Math

Emery, Marcia L.H.

Evolution

Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.

Reference

Muntoni, Francesco

Quinlivan, Rosaline C. M.

Words, Language & Grammar

Methodology in medical genetics: An introduction to statistical methods

Churchill Livingstone : distributed in the U.S.A. by Longman

Updated and revised, with new illustrations, diagrams and clinical photographs. There is also new information on molecular biology and molecular genetics and it is in a larger format and colour has been added for the first time. It is a text for students in preclinical as well as clincial years. An ELBS/LPBB edition is available.

Elements of medical genetics

Churchill/Livingstone

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Books by Emery, Alan E.H.

See the best price to sell, buy, or rent books by Emery, Alan E.H.. BookScouter helps to compare book prices from 25+ online bookstores and 30+ buyback vendors with a single search.

Duchenne Muscular Dystrophy (Oxford Monographs on Medical Genetics)

Duchenne Muscular Dystrophy (Oxford Monographs on Medical Genetics)

Duchenne Muscular Dystrophy (Oxford Monographs on Medical Genetics)

Muscular Dystrophy: The Facts (The ^AFacts Series)

Muscular Dystrophy: The Facts (The ^AFacts Series)

Muscular Dystrophy (The ^AFacts Series)

The History of a Genetic Disease: Duchenne Muscular Dystrophy or Meryon's Disease (Oxford Medical Histories)

Duchenne Muscular Dystrophy (Oxford Monographs on Medical Genetics)

Methodology in medical genetics: An introduction to statistical methods

Elements of medical genetics