The Great Imposter: The Amazing Careers of Ferdinand Waldo Demara

Crichton, Robert

Random House]

A Scottish girl living in the coal-mining town of Pitmungo, sets out on her sixteenth birthday to find a husband who will help her achieve social success

The Camerons

Literature & Fiction

Contemporary

Alfred A. Knopf, Inc.

Genre Fiction

Warner

Iron is of fundamental importance to the growth, development and well-being of almost all living organisms. Multiple biological systems have evolved for the uptake, utilisation, storage, and homeostasis of iron in microbes, plants and mammals. Both iron deficiency and iron overload are found extensively in humans; the intimate links between iron and oxidative stress are associated with a wide range of pathologies. Iron has a well established role in infections by a range of microorganisms and parasites. Other metals such as copper and zinc are also closely linked with iron metabolism. Iron overloads and deficiencies are important factors in the health of humans and are therefore a key target in drug development. 
Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, 3rd Edition presents a comprehensive overview of this important field.Topics covered include: <ul>
<li>Solution chemistry of iron in biological media</li> <li>The importance of iron for biological systems</li> <li>Microbial iron transport and metabolism</li> <li>Iron uptake by plants and fungi</li> <li>Cellular iron uptake and export in mammals</li> <li>Intracellular iron storage and biomineralization</li> <li>Intracellular iron metabolism and cellular iron homeostasis</li> <li>Iron absorption in mammals, with particular reference to man, and regulation of systemic iron balance</li> <li>Pathophysiology of iron deficiency and iron overload in man</li> <li>Iron and oxidative stress</li> <li>Brain iron homeostasis and its perturbation in various neurodegenerative diseases</li> <li>Interactions between iron and other metals</li> </ul>
Written in a lively style by one of the leaders in the field and presented in full colour, this third, expanded edition of Iron Metabolism has been fully updated with the latest discoveries. Major additions include recent information on mitochondrial iron metabolism and the role of frataxin; transcriptional control of iron homeostasis; orally active iron chelators; the roles of hepcidin and erythropoietin; the increasing number of types of iron overload; and the importance of iron in Alzheimer’s disease. Iron Metabolism is essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and the medical sciences. It will also find space on the bookshelves of bioinorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, and pharmacologists in the pharmaceutical industry interested in developing novel iron-binding drugs.

Iron Metabolism: From Molecular Mechanisms to Clinical Consequences

Science & Math

Biological Sciences

John Wiley&Sons, Inc.

This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. 
Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Medical Books

Ward, Roberta

Medicine

wiley

The Secret of Santa Vittoria

The clownish Bombolini becomes a man of significance when he devises a plan to prevent the Germans from taking Santa Vittoria's liquor supply

Carroll & Graf Pub.

Metal-Based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Health, Fitness & Dieting

Alternative Medicine

Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: <ul>
<li>Brain function, physiology and the blood-brain barrier</li> <li>Immune system and neuroinflammation</li> <li>Aging and mild cognitive impairment, MCI</li> <li>Parkinson’s Disease</li> <li>Alzheimer’s Disease</li> <li>Creutzfelt-Jakob and related prion diseases</li> <li>Alcoholic Brain Damage</li> <li>Therapeutic strategies to combat the onset and progression of neurological diseases</li> </ul>
This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

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